7beta,8-环氧-3beta,11alpha,14-三羟基-12-氧代-5beta-心甾-20(22)-烯内酯 | 22146-03-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 7beta,8-环氧-3beta,11alpha,14-三羟基-12-氧代-5beta-心甾-20(22)-烯内酯
• 英文名称: Sarverogenin
• 英文别名: (1R,3S,5S,7S,10S,11S,12S,14R,15R,18R)-7,12,18-trihydroxy-10,14-dimethyl-15-(5-oxo-2H-furan-3-yl)-2-oxapentacyclo[9.7.0.01,3.05,10.014,18]octadecan-13-one
• CAS: 22146-03-8
• 化学式: C₂₃H₃₀O₇
• 分子量: 418.5
• InChiKey: ACXJWHRFZUSCNC-QBOSKRDWSA-N

物化性质

• 熔点：
  melting at 232-234°
• 比旋光度：
  D15 +44.5 ± 2° (c = 1.1683 in methanol); D23 +49.5° (methanol)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Compositions and methods for delivery of genetic material
  申请人：Wyeth

  公开号：EP1616578A1

  公开（公告）日：2006-01-18

  Methods of introducing genetic material into cells of an individual and compositions and kits for practising the same are disclosed. The methods comprise the steps of contacting cells of an individual with a genetic vaccine facilitator and administering to the cells a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practising methods of the present invention are disclosed.

  本发明公开了将遗传物质导入人体细胞的方法以及用于实施该方法的组合物和试剂盒。这些方法包括以下步骤：用基因疫苗促进剂接触人体细胞，并给细胞注射不含逆转录病毒颗粒的核酸分子。核酸分子包括一个核苷酸序列，该序列编码一种蛋白质，该蛋白质包括至少一个表位，该表位与病原体抗原或与过度增殖性疾病或自身免疫性疾病相关的抗原的表位相同或基本相似；一种由于基因缺失、无功能或部分功能而在个体中缺失的蛋白质；或一种对个体产生治疗效果的蛋白质。本发明公开了预防性和治疗性免疫艾滋病病毒的方法。公开了用于实施本发明方法的药物组合物和试剂盒。
• 抗腫瘍療法
  申请人：——

  公开号：JP2002536415A

  公开（公告）日：2002-10-29

  \n (57)【要約】\n本発明は、有効量の強心配糖体または医薬塩を投与することを含む、腫瘍を処置するための新規方法、医薬組成物、および製造品を提供し、ここで、腫瘍は、中皮種、肉腫、癌腫、間質細胞、および胚細胞腫瘍からなる群から選択される。\n

  \(57)/n (57)/n 本发明提供了治疗肿瘤的新方法、药物组合物和制造品，包括施用有效量的强心苷或药物盐，其中肿瘤选自由间皮瘤、肉瘤、癌、基质细胞和生殖细胞肿瘤组成的组。\n
• Method of increasing satellite cell proliferation with an HDAC inhibitor
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US10660902B2

  公开（公告）日：2020-05-26

  The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.

  本发明提供了诱导、增强或增加卫星细胞增殖的方法，以及用于筛选诱导、增强或增加卫星细胞增殖的候选化合物的检测方法。本发明还提供了修复或再生受试者受损肌肉组织的方法。
• Small molecules for mouse satellite cell proliferation
  申请人：President and Fellows of Harvard College

  公开号：US11026952B2

  公开（公告）日：2021-06-08

  The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.

  本发明提供了诱导、增强或增加卫星细胞增殖的方法，以及用于筛选诱导、增强或增加卫星细胞增殖的候选化合物的检测方法。本发明还提供了修复或再生受试者受损肌肉组织的方法。
• Viral vaccine composition, process, and methods of use
  申请人：——

  公开号：US20030092145A1

  公开（公告）日：2003-05-15

  A composition for treating or preventing virus-induced infections is described, along with a process of producing the composition and methods of the composition's use. The composition comprises viral pathogen-infected cell or tissue, or malignantly or immunologically aberrant cells or tissues which has been reduced and/or denatured. The preferred composition is administered across a mucosal surface of an animal suffering or about suffer from infection. The composition is administered as preventive or therapeutic vaccine.

  本文描述了一种用于治疗或预防病毒引起的感染的组合物，以及该组合物的生产过程和使用方法。该组合物由受病毒病原体感染的细胞或组织，或恶性或免疫异常的细胞或组织组成，这些细胞或组织已被还原和/或变性。优选的组合物在遭受或即将遭受感染的动物粘膜表面给药。组合物可作为预防或治疗疫苗使用。