5-amino-2,4-bis(4-chlorophenyl)-2-methyl-7-(4-methylpiperazin-1-yl)-1,2-dihydro[1,6]naphthyridine-8-carbonitrile | 1319212-01-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-amino-2,4-bis(4-chlorophenyl)-2-methyl-7-(4-methylpiperazin-1-yl)-1,2-dihydro[1,6]naphthyridine-8-carbonitrile
• CAS: 1319212-01-5
• 化学式: C₂₇H₂₆Cl₂N₆
• 分子量: 505.45
• InChiKey: JHAWAUMDAYJRJO-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 对氯苯乙酮 、 丙二腈 以 水 为溶剂， 反应 3.0h， 以89%的产率得到5-amino-2,4-bis(4-chlorophenyl)-2-methyl-7-(4-methylpiperazin-1-yl)-1,2-dihydro[1,6]naphthyridine-8-carbonitrile
  参考文献：
  名称：

  An Expeditious and Efficient Synthesis of Highly Functionalized [1,6]-Naphthyridines under Catalyst-Free Conditions in Aqueous Medium

  摘要：

  This is the first report of an Innovative, one-pot, catalyst-free, pseudo-five-component synthesis of 1,2-dihydro[1,6]naphthyridines from methyl ketones, amines, and malononitrile In ecofriendly solvent water. The protocol avoids the use of expensive catalysts, toxic organic solvents and anhydrous condition. The approach to naphthyridines presented herein offers for the first time an unprecedented coupling which leads to the construction of both the nitrogen containing rings during the synthesis without starting from any nitrogen-containing heterocycle moiety.

  DOI：

  10.1021/ol201877v