Sicorten | 1310709-74-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Sicorten
• 英文别名: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one;hydrate
• CAS: 1310709-74-0
• 化学式: C22H29ClF2O6
• 分子量: 462.9
• InChiKey: LIVSBYNMLPEZHQ-DNGJBDHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.59
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  95.8
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• GLUCOCORTICOID COMBINED WITH POLYETHYLENE GLYCOL-MODIFIED INTERLEUKIN-2 FOR TREATING RESPIRATORY DISEASE
  申请人：Xie, Yanhui

  公开号：EP3431096A1

  公开（公告）日：2019-01-23

  The present invention provides an inhalable pharmaceutical composition comprising a glucocorticoid and a polyethylene glycol (PEG)-modified interleukin-2 for treating a respiratory disease. The invention further provides an application of a PEG-modified interleukin-2 for preparing a pharmaceutical composition for enhancing the efficacy of a glucocorticoid in treating the respiratory disease. The invention also provides a method for treating the respiratory disease.

  本发明提供了一种可吸入的药物组合物，该组合物包含一种糖皮质激素和一种聚乙二醇（PEG）修饰的白细胞介素-2，用于治疗呼吸系统疾病。本发明进一步提供了一种应用 PEG 改性白细胞介素-2 制备药物组合物的方法，以增强糖皮质激素治疗呼吸道疾病的疗效。本发明还提供了一种治疗呼吸系统疾病的方法。
• Molecularly imprinted polymer nanoparticles compatible with biological samples and preparation method thereof
  申请人：Nankai University

  公开号：US10053531B2

  公开（公告）日：2018-08-21

  This invention provides molecularly imprinted polymer nanoparticles compatible with biological samples, and in particular pure biological samples and a preparation method thereof. Said molecularly imprinted polymer nanoparticles have a crosslinking degree exceeding 50%, a particle diameter of 10 to 500 nm, hydrophilic polymer brushes on its surfaces and can be prepared by introducing appropriate hydrophilic macromolecular chain transfer agents into reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization systems through the one-pot synthesis. The preparation method is simple, features a broad range of application and yields a pure product. The obtained hydrophilic molecularly imprinted polymer nanoparticles have prospects for a wide range of application in biological sample analysis, medical clinical immune analysis, food and environmental monitoring, biomimetic sensors, etc.

  本发明提供了与生物样品，特别是纯生物样品相容的分子印迹聚合物纳米粒子及其制备方法。所述分子印迹聚合物纳米颗粒的交联度超过 50%，颗粒直径为 10 至 500 nm，表面具有亲水性聚合物刷，可通过在可逆加成-碎片链转移（RAFT）沉淀聚合体系中引入适当的亲水性大分子链转移剂，采用一锅合成法制备。该制备方法简单、应用范围广、产物纯度高。所获得的亲水性分子印迹聚合物纳米粒子在生物样品分析、医学临床免疫分析、食品和环境监测、仿生传感器等方面具有广泛的应用前景。
• Topical formulations comprising a steroid
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：US10064875B2

  公开（公告）日：2018-09-04

  The application provides formulations for the topical administration of an active agent comprising at least one steroid, in the form of topical sprays that are propellant-free, and/or substantially non-foaming, and/or alcohol-free. The present application also provides processes for preparing such compositions and methods of using them in management of skin diseases or disorders such as psoriasis, dermatoses, and other associated skin diseases or disorders.

  本申请提供了用于局部施用至少一种类固醇活性剂的制剂，其形式为不含推进剂和/或基本不起泡和/或不含酒精的局部喷雾剂。本申请还提供了制备此类组合物的工艺，以及将其用于治疗牛皮癣、皮肤病等皮肤疾病的方法。
• Glucocorticoid combined with polyethylene glycol-modified interleukin 2 for treating respiratory disease
  申请人：Xie Yanhui

  公开号：US10898576B2

  公开（公告）日：2021-01-26

  The present invention provides an inhalable pharmaceutical composition comprising a glucocorticoid and a polyethylene glycol (PEG)-modified interleukin-2 for treating a respiratory disease. The invention further provides an application of a PEG-modified interleukin-2 for preparing a pharmaceutical composition for enhancing the efficacy of a glucocorticoid in treating the respiratory disease. The invention also provides a method for treating the respiratory disease.

  本发明提供了一种可吸入的药物组合物，该组合物包含一种糖皮质激素和一种聚乙二醇（PEG）修饰的白细胞介素-2，用于治疗呼吸系统疾病。 本发明进一步提供了一种应用 PEG 改性白细胞介素-2 制备药物组合物的方法，以增强糖皮质激素治疗呼吸道疾病的疗效。 本发明还提供了一种治疗呼吸系统疾病的方法。
• Topical compositions comprising a corticosteroid
  申请人：PRIMUS PHARMACEUTICALS, INC.

  公开号：US11179465B2

  公开（公告）日：2021-11-23

  Topical compositions comprising a corticosteroid, at least one alcohol, and a penetration enhancing agent.

  由皮质类固醇、至少一种酒精和一种渗透增强剂组成的外用组合物。