2-Amino-4-tetrahydrochinolino-6-chlormethyl-triazin-(1,3,5) | 108846-90-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Amino-4-tetrahydrochinolino-6-chlormethyl-triazin-(1,3,5)
• 英文别名: 2-Amino-6-chlormethyl-4-tetrahydrochinolino-s-triazin；4-chloromethyl-6-(3,4-dihydro-2H-quinolin-1-yl)-[1,3,5]triazin-2-ylamine；4-(chloromethyl)-6-(3,4-dihydroquinolin-1(2H)-yl)-1,3,5-triazin-2-amine；4-(chloromethyl)-6-(3,4-dihydro-2H-quinolin-1-yl)-1,3,5-triazin-2-amine
• CAS: 108846-90-8
• 化学式: C₁₃H₁₄ClN₅
• mdl: MFCD03903835
• 分子量: 275.741
• InChiKey: YFVGHUYNDXBRNV-UHFFFAOYSA-N

物化性质

• 熔点：
  135-147 °C
• 沸点：
  520.6±60.0 °C(Predicted)
• 密度：
  1.370±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE
  申请人：Deshaies Raymond J.

  公开号：US20110288082A1

  公开（公告）日：2011-11-24

  Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof
• US8865708B2
  申请人：——

  公开号：US8865708B2

  公开（公告）日：2014-10-21
• [EN] METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE<br/>[FR] MÉTHODES ET COMPOSITIONS POUR L'INHIBITION DE L'ATPASE TRANSITIONNELLE DU RÉTICULUM ENDOPLASMIQUE
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2011140527A2

  公开（公告）日：2011-11-10

  Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.