O2N(Cl)C6H3C6HMe(OBn)(OH)SnPh3 | 1017280-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: O2N(Cl)C6H3C6HMe(OBn)(OH)SnPh3
• CAS: 1017280-62-4
• 化学式: C₃₇H₂₈ClNO₄Sn
• 分子量: 704.797
• InChiKey: FBGPDUJPMRYRJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.58
• 重原子数：
  44.0
• 可旋转键数：
  9.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  72.6
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  TMSOC6H4Me2OBn 、 O2NC6H3ClCCSnPh3 在 potassium carbonate 作用下， 以 neat (no solvent) 为溶剂， 以33%的产率得到O2N(Cl)C6H3C6HMe(OBn)(OH)SnPh3
  参考文献：
  名称：

  Synthesis of Programmable Tetra-ortho-Substituted Biaryl Compounds Using Diels−Alder Cycloadditions/Cycloreversions of Disubstituted Alkynyl Stannanes

  摘要：

  Orthogonally functionalized, programmable biaryl templates have been synthesized utilizing aryl acetylenic stannanes and oxygenated dienes in a cycloaddition/cycloreversion strategy. Sequential functionalization of each of the four ortho positions has been demonstrated. Subsequent resolution of a representative anilino phenol has been accomplished. Additionally, a highly active anhydrous, boroxine-based Suzuki coupling protocol has been developed for conversion of unreactive aryl chlorides.

  DOI：

  10.1021/ja7113486