雷美替胺杂质24 | 896736-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 雷美替胺杂质24
• 英文名称: N-[2-[(8R)-6-oxo-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propionamide
• 英文别名: 6-Oxo-ramelteon；N-[2-[(8R)-6-oxo-1,2,7,8-tetrahydrocyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
• CAS: 896736-22-4
• 化学式: C₁₆H₁₉NO₃
• 分子量: 273.332
• InChiKey: NWAGAOSALVFUPI-SNVBAGLBSA-N

物化性质

• 沸点：
  507.8±50.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  雷美替胺杂质24 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以0.74 g的产率得到N-[2-[(8R)-6-hydroxy-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propionamide
  参考文献：
  名称：

  CN115477628

  摘要：

  公开号：
• 作为产物：
  描述：

  雷美替胺 在 potassium permanganate 、 magnesium sulfate 作用下， 以 水 、 丙酮 为溶剂， 以0.78 g的产率得到雷美替胺杂质24
  参考文献：
  名称：

  CN115477628

  摘要：

  公开号：

文献信息

• AGENT FOR PREVENTION/TREATMENT OF IRRITABLE BOWEL SYNDROME
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1997488A1

  公开（公告）日：2008-12-03

  The present invention provides a prophylactic or therapeutic agent for irritable bowel syndrome, which comprises a compound represented by formula (I): wherein, R1 represents an optionally substituted hydrocarbon group, etc., R2 represents a hydrogen atom or an optionally substituted hydrocarbon group, R3 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc., X represents CHR4, NR4, CO, O or S (wherein, R4 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc.),Y represents C, CH or N, represents a single bond or double bond, ring A represents an optionally substituted 5- to 7-membered oxygen-containing heterocyclic ring, ring B represents an optionally substituted benzene ring, and m represents an integer of 1 to 4, or a salt thereof.

  本发明提供了一种肠易激综合征的预防或治疗剂，它由式 (I) 所代表的化合物组成： 其中，R1 代表任选取代的烃基等，R2 代表氢原子或任选取代的烃基，R3 代表氢原子、任选取代的烃基等、X 代表 CHR4、NR4、CO、O 或 S（其中，R4 代表氢原子、任选取代的烃基等），Y 代表 C、CH 或 N，代表单键或双键，环 A 代表任选取代的 5 至 7 元含氧杂环，环 B 代表任选取代的苯环，m 代表 1 至 4 的整数，或其盐。
• PROPHYLACTIC OR THERAPEUTIC AGENT FOR ATTENTION DEFICIT/HYPERACTIVITY DISORDER
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2248808A1

  公开（公告）日：2010-11-10

  The present invention provides a novel prophylactic or therapeutic agent for attention deficit/hyperactivity disorder. A prophylactic or therapeutic agent for attention deficit/hyperactivity disorder, containing (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide as an active ingredient.

  本发明提供了一种新型预防或治疗注意缺陷/多动障碍的药物。 一种用于注意缺陷/多动症的预防或治疗剂，含有(S)-N-[2-(1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基)乙基]丙酰胺作为活性成分。
• Prophylactic or Therapeutic Agent for Irritable Bowel Syndrome
  申请人：Terauchi Jun

  公开号：US20090048325A1

  公开（公告）日：2009-02-19

  The present invention provides a prophylactic or therapeutic agent for irritable bowel syndrome, which comprises a compound represented by formula (I): wherein, R 1 represents an optionally substituted hydrocarbon group, etc., R 2 represents a hydrogen atom or an optionally substituted hydrocarbon group, R 3 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc., X represents CHR 4 , NR 4 , CO, O or S (wherein, R 4 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc.), Y represents C, CH or N, represents a single bond or double bond, ring A represents an optionally substituted 5- to 7-membered oxygen-containing heterocyclic ring, ring B represents an optionally substituted benzene ring, and m represents an integer of 1 to 4, or a salt thereof.
• PROPHYLACTIC OR THERAPEUTIC AGENT FOR IRRITABLE BOWEL SYNDROME
  申请人：Terauchi Jun

  公开号：US20100267821A1

  公开（公告）日：2010-10-21

  The present invention provides a prophylactic or therapeutic agent for irritable bowel syndrome, which comprises a compound represented by formula (I): wherein, R 1 represents an optionally substituted hydrocarbon group, etc., R 2 represents a hydrogen atom or an optionally substituted hydrocarbon group, R 3 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc., X represents CHR 4 , NR 4 , CO, O or S (wherein, R 4 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc.), Y represents C, CH or N, represents a single bond or double bond, ring A represents an optionally substituted 5- to 7-membered oxygen-containing heterocyclic ring, ring B represents an optionally substituted benzene ring, and m represents an integer of 1 to 4, or a salt thereof.
• US8183285B2
  申请人：——

  公开号：US8183285B2

  公开（公告）日：2012-05-22