N-[2-((benzo[b]thiophene-2-carbonyl)oxy)propyl]-N,N-dimethylcyclohexanaminium iodide | 1431326-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-[2-((benzo[b]thiophene-2-carbonyl)oxy)propyl]-N,N-dimethylcyclohexanaminium iodide
• 英文别名: 2-(1-Benzothiophene-2-carbonyloxy)propyl-cyclohexyl-dimethylazanium;iodide
• CAS: 1431326-32-7
• 化学式: C₂₀H₂₈NO₂S*I
• 分子量: 473.418
• InChiKey: SZWCMUWSKPBFKT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Cyclohexylamines
  申请人：Endo Pharmaceuticals, Inc.

  公开号：US20130101667A1

  公开（公告）日：2013-04-25

  The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.

  本申请提供了新颖的化合物以及制备和使用这些化合物的方法。这些化合物在治疗疼痛、瘙痒、膀胱过度活跃和/或间质性膀胱炎患者中是有用的，通过向患者施用一个或多个这些化合物。这些方法包括给患者施用式(I)的化合物和TRPV1受体激活剂。在一个实施例中，TRPV1受体激活剂是利多卡因。
• CYCLOHEXYLAMINES
  申请人：Endo Pharmaceuticals Inc.

  公开号：US20140213552A1

  公开（公告）日：2014-07-31

  The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.

  本申请提供了新颖的化合物以及制备和使用这些化合物的方法。这些化合物可通过向患者投药来治疗疼痛、瘙痒、过度活跃的膀胱和/或间质性膀胱炎。该方法包括给患者投药化合物公式(I)和TRPV1受体激活剂。在一种实施方式中，TRPV1受体激活剂为利多卡因。
• US9180115B2
  申请人：——

  公开号：US9180115B2

  公开（公告）日：2015-11-10
• [EN] CYCLOHEXYLAMINES<br/>[FR] CYCLOHEXYLAMINES
  申请人：ENDO PHARMACEUTICALS INC

  公开号：WO2013063127A1

  公开（公告）日：2013-05-02

  The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPVl receptor activator. In one embodiment, the TRPVl receptor activator is lidocaine.