1-(2,3-Dihydro-1,4-benzoxazin-4-yl)-3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropan-2-ol | 1253796-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 1-(2,3-Dihydro-1,4-benzoxazin-4-yl)-3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropan-2-ol
• CAS: 1253796-73-4
• 化学式: C₂₁H₃₃NO₃
• 分子量: 347.498
• InChiKey: FHYWOIVUQSRYMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[(2-异丙基-5-甲基-环己氧基)甲基]环氧乙烷 、 3,4-二氢-2H-1,4-苯并噁嗪 在 水 作用下， 反应 24.0h， 以7.2%的产率得到1-(2,3-Dihydro-1,4-benzoxazin-4-yl)-3-(5-methyl-2-propan-2-ylcyclohexyl)oxypropan-2-ol
  参考文献：
  名称：

  [EN] ANALGESIC THAT BINDS FILAMIN A
  [FR] ANALGÉSIQUE QUI SE LIE À LA FILAMINE A

  摘要：

  公开了一种化合物、组合物及方法，能够提供镇痛效果。所考虑的化合物具有与式A相对应的结构，其中A、B、X、R1、R2、R7和R8以及虚线均在定义范围内。

  公开号：

  WO2010051374A1

文献信息

• ANALGESIC THAT BINDS FILAMIN A
  申请人：Burns Barbier Lindsay

  公开号：US20100279997A1

  公开（公告）日：2010-11-04

  A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R 1 , R 2 , R 7 and R 8 , and the dashed lines are defined within.

  公开了一种可以提供镇痛作用的化合物、组合物和方法。考虑到的化合物具有与A公式相对应的结构，其中A、B、X、R1、R2、R7和R8以及虚线在其中定义。
• Alzheimer's Disease Assay in a Living Patient
  申请人：Pain Therapeutics, Inc.

  公开号：US20210389298A1

  公开（公告）日：2021-12-16

  An assay for Alzheimer's disease pathology (AD) in a living patient is disclosed wherein an amount of α7nAChR or TLR4 in a FLNA-captured protein complex or α7nAChR in an Aβ-captured protein complex or α7nAChR-FLNA, TLR4-FLNA and/or α7nAChR-Aβ 42 complex present as a protein-protein complex in a sample is determined and compared to the amount in a standard sample from a person free of AD pathology. An amount greater than in the standard sample indicates AD pathology. Also disclosed is an assay predictive of prognosis for treatment with a medicament in which the amount of an above protein or protein complex is determined and compared to an amount determined in the presence of a medicament that binds to a FLNA pentapeptide and contains at least four of the six pharmacophores of FIGS. 7 - 12 . An amount of protein or protein complex determined in the presence of the medicament less than the first determined amount indicates a favorable treatment prognosis.
• [EN] ANALGESIC THAT BINDS FILAMIN A<br/>[FR] ANALGÉSIQUE QUI SE LIE À LA FILAMINE A
  申请人：PAIN THERAPEUTICS INC

  公开号：WO2010051374A1

  公开（公告）日：2010-05-06

  A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within.

  公开了一种化合物、组合物及方法，能够提供镇痛效果。所考虑的化合物具有与式A相对应的结构，其中A、B、X、R1、R2、R7和R8以及虚线均在定义范围内。