5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-4-pyrene β-deoxynucleoside | 1388771-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-4-pyrene β-deoxynucleoside
• CAS: 1388771-66-1
• 化学式: C₄₄H₃₈O₆
• 分子量: 662.782
• InChiKey: WMMCUBJKHVYRHE-RJBDQUNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.37
• 重原子数：
  50.0
• 可旋转键数：
  10.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  63.22
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-4-pyrene β-deoxynucleoside 在 二氯乙酸 、 甲醇 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 以77%的产率得到3'-O-acetyl-4-pyrene β-deoxynucleoside
  参考文献：
  名称：

  Polymerase incorporation of pyrene-nucleoside triphosphates

  摘要：

  Pyrene-deoxynucleoside triphosphates (dPTPs), varying by the positioning of the aromatic system, were synthesized. Their ability to function as substrates for the Klenow fragment of Escherichia coli DNA polymerase I and the TdT polymerase was assessed. The dPTPs are all equally well tolerated by the Klenow fragment, and lead to elongation of up to 5 extra nucleotides of a ssDNA primer in a TdT-mediated reaction. The tailing efficiency of the dPTPs compares favorably to other less drastically modified dNTPs. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.101
• 作为产物：
  描述：

  、 乙酸酐 在 吡啶 作用下， 反应 12.0h， 以100%的产率得到5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-4-pyrene β-deoxynucleoside
  参考文献：
  名称：

  Polymerase incorporation of pyrene-nucleoside triphosphates

  摘要：

  Pyrene-deoxynucleoside triphosphates (dPTPs), varying by the positioning of the aromatic system, were synthesized. Their ability to function as substrates for the Klenow fragment of Escherichia coli DNA polymerase I and the TdT polymerase was assessed. The dPTPs are all equally well tolerated by the Klenow fragment, and lead to elongation of up to 5 extra nucleotides of a ssDNA primer in a TdT-mediated reaction. The tailing efficiency of the dPTPs compares favorably to other less drastically modified dNTPs. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.101