[2-(3-benzo[1,3]dioxol-5-yl-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-4-yloxy)-ethyl]-carbamic acid tert-butyl ester | 1438402-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [2-(3-benzo[1,3]dioxol-5-yl-7-fluoro-1-oxo-1,2-dihydro-isoquinolin-4-yloxy)-ethyl]-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-[2-[[3-(1,3-benzodioxol-5-yl)-7-fluoro-1-oxo-2H-isoquinolin-4-yl]oxy]ethyl]carbamate
• CAS: 1438402-95-9
• 化学式: C₂₃H₂₃FN₂O₆
• 分子量: 442.444
• InChiKey: AEFNGRAYPRIQDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 3-PHENYL-ISOQUINOLIN-1(2H)-ONE DERIVATIVES AS PARP-1 INHIBITORS
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US20140336192A1

  公开（公告）日：2014-11-13

  There are provided substituted 3-phenyl-isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with respect to poly(ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

  提供了替代的3-苯基异喹啉-1(2H)-酮衍生物，其选择性地抑制了聚(ADP-核糖)聚合酶PARP-1的活性，而对聚(ADP-核糖)聚合酶PARP-2则没有影响。因此，本发明的化合物可用于治疗癌症、心血管疾病、中枢神经系统损伤和不同形式的炎症等疾病。本发明还提供了制备这些化合物的方法、包含这些化合物的制药组合物以及利用包含这些化合物的制药组合物治疗疾病的方法。
• Amino photo-reactive binder
  申请人：Allnex Belgium S.A.

  公开号：US10000446B2

  公开（公告）日：2018-06-19

  A compound obtained by reaction of one or more amines of the general formula NHR6R7 with a compound of the following general formula (IX): wherein, PI is a photoinitiator derivative, G is linker comprising a number p′ of unreacted hydroxyl groups, M is a group comprising a number z of (meth)acrylate groups equal to at least one, as well as inks, coating compositions and adhesives comprising the same.

  一种化合物，由一种或多种通式 NHR6R7 的胺与下述通式 (IX) 的化合物反应而得： 其中 PI 是光引发剂衍生物、 G 是由数量为 p′ 的未反应羟基组成的连接剂、 M 是由至少一个（甲基）丙烯酸酯基团 z 组成的基团，以及包含这些基团的油墨、涂料组合物和粘合剂。
• Photo-reactive binder
  申请人：Allnex Belgium S.A.

  公开号：US10005717B2

  公开（公告）日：2018-06-26

  A compound obtained by reaction of one or more amines of general formula NHR6R7 with a benzophenone derivative of the following general formula (IX) wherein M is a group comprising a number z of (meth)acrylate groups equal to at least one, L is a linker, G is linker comprising a number p′ of unreacted hydroxyl groups, and R, R″ and R′″ are optional substituents as well as inks, coating compositions and adhesives comprising the same.

  一种化合物，由一种或多种通式 NHR6R7 的胺与下式（IX）的二苯甲酮衍生物反应而得 其中 M 是由至少一个（甲基）丙烯酸酯基团 z 组成的基团、 L 是连接剂 G 是由数量为 p′的未反应羟基组成的连接体，以及 R、R″和 R′″为任选取代基 以及由其组成的油墨、涂料组合物和粘合剂。
• Polymeric photoinitiators
  申请人：Allnex Belgium S.A.

  公开号：US10189930B2

  公开（公告）日：2019-01-29

  The present invention relates to radiation curable compositions (A) comprising—(a) at least one photoinitiator compound of formula (I) wherein Q is the residue of a hydroxy compound having 1 to 6 hydroxyl groups, and wherein x is a number that is at least 1 but no greater than the number of hydroxyl groups originally present in said hydroxy compound;—(b) at least one ethylenically unsaturated compound selected from monomers (b1) and/or from oligomers (b2); and—(c) optionally, at least one co-synergist which preferably is an amino co-synergist. The present invention further relates to photoinitiator compounds(a) and their preparation.

  本发明涉及可辐射固化的组合物(A)，包括-(a) 至少一种式(I)的光引发剂化合物，其中 Q 是具有 1 至 6 个羟基的羟基化合物的残基，x 是至少为 1 但不大于所述羟基化合物中原有羟基数目的数字；-(b) 至少一种乙烯基不饱和化合物，选自单体 (b1) 和/或低聚物 (b2)；以及- (c) 可选地，至少一种助增效剂，最好是氨基助增效剂。本发明进一步涉及光引发剂化合物（a）及其制备。
• AMINO PHOTO-REACTIVE BINDER
  申请人：Allnex Belgium S.A.

  公开号：EP2804849B1

  公开（公告）日：2018-06-27