(1S,2R)-2-(dimethylamino)-3-methoxy-1-phenylpropane-1-thiol | 1186329-51-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1S,2R)-2-(dimethylamino)-3-methoxy-1-phenylpropane-1-thiol
• CAS: 1186329-51-0
• 化学式: C₁₂H₁₉NOS
• 分子量: 225.355
• InChiKey: NZXYXIKXCLADFH-NEPJUHHUSA-N

反应信息

• 作为产物：
  描述：

  (S)-(1S,2R)-2-(dimethylamino)-3-methoxy-1-phenylpropyl ethanethioate 在 二异丁基氢化铝 、 甲醇 作用下， 以 乙醚 、 正己烷 为溶剂， 以50%的产率得到(1S,2R)-2-(dimethylamino)-3-methoxy-1-phenylpropane-1-thiol
  参考文献：
  名称：

  Amino thiols versus amino alcohols in the asymmetric alkynylzinc addition to aldehydes

  摘要：

  A series of modular amino thiol and amino alcohol ligands have been synthesized in enantiopure form from common enantiopure precursors. Their structures have been optimized for performance in the asymmetric alkynylzinc addition to aldehydes, and a direct comparison of the effect of the S and 0 coordinating atoms on the catalytic outcome of these ligands has been performed. Amino thiols have shown to be superior as ligands for this type of chemistry. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.05.029