3-羟基苄肼二盐酸盐

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 3-羟基苄肼二盐酸盐
• 中文别名: 3-羟基苯甲酰肼二盐酸盐
• 英文名称: 3-(Hydrazinylmethyl)phenol;hydron;dichloride
• 英文别名: 3-(hydrazinylmethyl)phenol;hydron;dichloride
• 化学式: C7H12Cl2N2O
• mdl: MFCD00044695
• 分子量: 211.09
• InChiKey: ONOJPUDFIOEGCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.45
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  58.3
• 氢给体数：
  5
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methyl-4-(acetacetyl)-1-phenyl-2-pyrazolin-5-one 、 3-羟基苄肼二盐酸盐 生成 2-(3-hydroxy-benzyl)-5,5'-dimethyl-2'-phenyl-2H,2'H-[3,4']bipyrazolyl-3'-ol
  参考文献：
  名称：

  DIPYRAZOLE COMPOUNDS AND THEIR USE AS CENTRAL NERVOUS SYSTEM AGENTS

  摘要：

  本发明涉及公式I的二吡唑化合物及其药学上可接受的盐、立体异构体、互变异构体或溶剂化物。新型化合物包括公式I的化合物。本发明的化合物调节AMPA和NMDA受体功能，因此可用作药物，特别是用于治疗神经精神障碍。

  公开号：

  US20080090872A1

文献信息

• [EN] SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] 4-(INDAZOL-3-YL)PHENOLS SUBSTITUES COMME LIGANDS DU RECEPTEUR DES OESTROGENES ET LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES
  申请人：WYETH CORP

  公开号：WO2004031159A1

  公开（公告）日：2004-04-15

  This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease. Arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

  这项发明提供了具有结构的化合物I或II的公式，其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10如规范中定义，或其药用盐，这些化合物对治疗疾病的炎症成分有用，特别适用于治疗动脉粥样硬化、心肌梗死、充血性心力衰竭、炎症性肠病、关节炎、2型糖尿病以及多发性硬化和类风湿关节炎等自身免疫疾病。
• Substituted 4-(indazol-3-yl)phenols
  申请人：Wyeth

  公开号：US20040167127A1

  公开（公告）日：2004-08-26

  This invention provides compound of formulae I or II having the structure 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

  本发明提供了式I或式II的化合物，其结构为1，其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10如规范中所定义，或其药学上可接受的盐，其对于疾病的炎症成分具有治疗作用，尤其是在治疗动脉粥样硬化、心肌梗死、充血性心力衰竭、炎症性肠病、关节炎、2型糖尿病以及自身免疫性疾病如多发性硬化和类风湿性关节炎方面特别有用。
• Substituted 4-(Indazol-3-yl)phenols
  申请人：Steffan J. Robert

  公开号：US20070225349A1

  公开（公告）日：2007-09-27

  This invention provides compound of formulae I or II having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.

  该发明提供了式I或II的化合物，其结构为： 其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10如规范中所定义，或其药学上可接受的盐，用于治疗疾病的炎症成分，特别适用于治疗动脉硬化、心肌梗塞、充血性心力衰竭、炎症性肠病、关节炎、II型糖尿病以及多发性硬化和风湿性关节炎等自身免疫疾病。
• DIPYRAZOLE COMPOUNDS AND THEIR USE AS CENTRAL NERVOUS SYSTEM AGENTS
  申请人：KOSLEY W. Raymond

  公开号：US20080090872A1

  公开（公告）日：2008-04-17

  The present invention is directed to dipyrazole compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I. The compounds of this invention modulate AMPA and NMDA receptor function, and therefore are useful as pharmaceutical agents, especially for the treatment of neuropsychiatric disorders.

  本发明涉及公式I的二吡唑化合物及其药学上可接受的盐、立体异构体、互变异构体或溶剂化物。新型化合物包括公式I的化合物。本发明的化合物调节AMPA和NMDA受体功能，因此可用作药物，特别是用于治疗神经精神障碍。
• CFTR INHIBITOR COMPOUNDS AND USES THEREOF
  申请人：Russell Michael Geoffrey Neil

  公开号：US20080269206A1

  公开（公告）日：2008-10-30

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-6 or encompassed by formulas I-VI) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物中一种对抑制囊性纤维化跨膜传导调节因子（CFTR）多肽的功能反应的疾病的组合物和方法，通过向需要治疗该疾病的哺乳动物中给予本文所定义的化合物（包括表1-6中列出的化合物或被公式I-VI所包含的化合物）或其组合物的有效量，从而治疗该疾病。本发明特别涉及治疗腹泻和多囊肾病的方法。

表征谱图