3-[1-(methylsulfonyl)piperidin-4-yl]-7-(2-naphthyl)-3H-imidazo[4,5-b]pyridine | 1127118-10-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-[1-(methylsulfonyl)piperidin-4-yl]-7-(2-naphthyl)-3H-imidazo[4,5-b]pyridine
• 英文别名: 3-(1-Methylsulfonylpiperidin-4-yl)-7-naphthalen-2-ylimidazo[4,5-b]pyridine
• CAS: 1127118-10-8
• 化学式: C₂₂H₂₂N₄O₂S
• 分子量: 406.508
• InChiKey: BWKNHLQVRRKUFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  76.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM
  申请人：Lundquist, IV Joseph Theodore

  公开号：US20090069319A1

  公开（公告）日：2009-03-12

  The present invention relates to imidazopyridine analogs, methods of making imidazopyridine analogs, compositions comprising an imidazopyridine analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of an imidazopyridine analog.

  本发明涉及咪唑吡啶类似物，制备咪唑吡啶类似物的方法，包含咪唑吡啶类似物的组合物，以及治疗经典Wnt-β-catenin细胞信使系统相关疾病的方法，包括向需要的受试者施用有效量的咪唑吡啶类似物。
• [EN] IMIDAZOPYRIDINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM<br/>[FR] ANALOGUES DE L'IMIDAZOPYRIDINE ET LEUR UTILISATION EN TANT QU'AGONISTES DU SYSTÈME DE MESSAGERIE CELLULAIRE WNT-BÊTA-CATÉNINE
  申请人：WYETH CORP

  公开号：WO2009029609A1

  公开（公告）日：2009-03-05

  The present invention relates to imidazopyridine analogs, methods of making imidazopyridine analogs, compositions comprising an imidazopyridine analog, and methods for treating canonical Wnt-ß-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of an imidazopyridine analog.