2-Methyl-5-phenyltetrahydrothiophen-3-on | 36748-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻烷
• 英文名称: 2-Methyl-5-phenyltetrahydrothiophen-3-on
• 英文别名: 2-methyl-5-phenyl-dihydro-thiophen-3-one；2-Methyl-5-phenylthiolan-3-one
• CAS: 36748-20-6
• 化学式: C₁₁H₁₂OS
• 分子量: 192.282
• InChiKey: CLXUXGLKNCGLGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS
  申请人：Frutos Rogelio Perez

  公开号：US20110130563A1

  公开（公告）日：2011-06-02

  The present invention relates to an improved process for the preparation of dihydrothieno[3,2-d]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
• US8471010B2
  申请人：——

  公开号：US8471010B2

  公开（公告）日：2013-06-25