ethyl 6-(4-(4-fluoro-2-methyl-1H-indol-5-ylamino)-7-(3-(pyrrolidin-1-yl)propoxy)-quinazolin-6-yloxy)hexanoate | 1133461-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 6-(4-(4-fluoro-2-methyl-1H-indol-5-ylamino)-7-(3-(pyrrolidin-1-yl)propoxy)-quinazolin-6-yloxy)hexanoate
• 英文别名: ethyl 6-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)amino]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-6-yl]oxyhexanoate
• CAS: 1133461-93-4
• 化学式: C₃₂H₄₀FN₅O₄
• 分子量: 577.699
• InChiKey: CCQJIXAHTZCHOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  42
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY
  申请人：Qian Changgeng

  公开号：US20090076044A1

  公开（公告）日：2009-03-19

  The present invention relates to VEGFR inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.

  本发明涉及VEGFR抑制剂及其在治疗细胞增殖性疾病如癌症中的应用。所述衍生物还可能作为HDAC抑制剂。
• [EN] VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY<br/>[FR] INHIBITEURS DE VEGFR CONTENANT UNE FRACTION DE LIAISON AU ZINC
  申请人：CURIS INC

  公开号：WO2009036055A1

  公开（公告）日：2009-03-19

  The present invention relates to VEGFR inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.