N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(trifluoromethylthio)ethylamino)methyl)-2-furyl)-quinazolin-4-amine | 1275595-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(trifluoromethylthio)ethylamino)methyl)-2-furyl)-quinazolin-4-amine
• 英文别名: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[2-(trifluoromethylsulfanyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine
• CAS: 1275595-91-9
• 化学式: C₂₉H₂₃ClF₄N₄O₂S
• 分子量: 603.04
• InChiKey: IAYRLQAQEYUBCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  41
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  97.5
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• 4-(Substituted Anilino)-Quinazoline Derivatives Useful as Tyrosine Kinase Inhibitors
  申请人：Wang Jingyi

  公开号：US20120208833A1

  公开（公告）日：2012-08-16

  The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositions and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.

  本发明涉及作为酪氨酸激酶抑制剂的4-(取代苯胺基)-喹唑啉衍生物。具体地，公开了式I的化合物，或其药学上可接受的盐或溶剂化合物，其中式I中的每个取代基在描述中有定义。还公开了式I化合物的制备方法，药物组合物以及其药用。式I化合物是有效的酪氨酸激酶抑制剂。
• 4-(SUBSTITUTED ANILINO)QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS
  申请人：Qilu Pharmaceutical Co., Ltd

  公开号：EP2484678A1

  公开（公告）日：2012-08-08

  The present invention relates to 4-(substituted anilino)-quinazoline derivatives as tyrosine kinase inhibitors. Specifically, compounds of formula I, or pharmaceutically acceptable salts or solvates thereof are disclosed, in which each substitutent in formula I is defined in the description. Preparation method of the compounds of formula I, pharmaceutical compositons and pharmaceutical uses thereof are also disclosed. The compounds of formula I are effective tyrosine kinase inhibitors.

  本发明涉及作为酪氨酸激酶抑制剂的 4-(取代苯胺基)-喹唑啉衍生物。具体而言，本发明公开了式 I 的化合物或其药学上可接受的盐或溶液，其中式 I 中的各取代基在描述中定义。还公开了式 I 化合物的制备方法、药物组合物及其药物用途。式 I 化合物是有效的酪氨酸激酶抑制剂。
• US8916574B2
  申请人：——

  公开号：US8916574B2

  公开（公告）日：2014-12-23