benzyl(1H-indazol-3-yl)amine | 954-96-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: benzyl(1H-indazol-3-yl)amine
• 英文别名: 3-Benzylamino-indazol；benzyl-(1(2)H-indazol-3-yl)-amine；N-benzyl-1H-indazol-3-amine
• CAS: 954-96-1
• 化学式: C₁₄H₁₃N₃
• 分子量: 223.277
• InChiKey: JCSQXEINQFERDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-benzyl-2-fluorobenzothioamide 在 肼 作用下， 以 二甲基亚砜 为溶剂， 以75%的产率得到benzyl(1H-indazol-3-yl)amine
  参考文献：
  名称：

  An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles

  摘要：

  A non-acidic procedure for the preparation of 3-aminoindazoles and 3-amino-7-azaindazoles from 2-fluoroaryl carboxylic acids is reported. The synthesis starts from readily available starting materials and uses mild and practical reaction conditions in a three-step overall procedure. Products were isolated for a number of examples, but yields varied significantly depending on electronic nature of the substituents. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.100

文献信息

• [EN] DERIVATIVES OF AZAINDOLES AS INHIBITORS OF PROTEIN KINASES ABL AND SRC<br/>[FR] DÉRIVÉS D'AZAINDOLES COMME INHIBITEURS DES PROTÉINES KINASES ABL ET SRC
  申请人：NOVA DECISION

  公开号：WO2010092489A1

  公开（公告）日：2010-08-19

  The present invention relates to compounds of general formula I and use thereof as inhibitors of protein kinases AbI and Src and the method of production thereof. The present invention also relates to pharmaceutical compositions and medicinal products comprising these compounds.

  本发明涉及一般式I的化合物及其作为蛋白激酶AbI和Src的抑制剂的用途，以及其生产方法。本发明还涉及包含这些化合物的药物组合物和药品。
• Derivatives of Azaindoles as Inhibitors of Protein Kinases ABL and SRC
  申请人：Yasri Abdelaziz

  公开号：US20110312959A1

  公开（公告）日：2011-12-22

  The present invention relates to compounds of general formula I and use thereof as inhibitors of protein kinases AbI and Src and the method of production thereof. The present invention also relates to pharmaceutical compositions and medici-nal products comprising these compounds.

  本发明涉及一般式I的化合物及其作为蛋白激酶AbI和Src的抑制剂的用途，以及其生产方法。本发明还涉及包含这些化合物的制药组合物和药物产品。
• INDAZOLE COMPOUND-CONTAINING COMPOSITION AND LIGHT-EMITTING DEVICE USING THE COMPOSITION
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2119753A1

  公开（公告）日：2009-11-18

  Disclosed is a composition containing a compound having an indazole ring structure and a phosphorescent compound.

  本发明公开了一种组合物，其中含有一种具有吲唑环结构的化合物和一种磷光化合物。
• Indazole compound-containing composition and light-emitting device using the composition
  申请人：SUMITOMO CHEMICAL CO., LTD.

  公开号：EP2479236A1

  公开（公告）日：2012-07-25

  The present application relates to a composition comprising a compound having an indazole ring structure and a phosphorescence-emitting compound, wherein the compound having an indazole ring structure is a polymer comprising a repeating unit which is an indazole ring structure represented by the general formula (1-1), (1-2), (1-3), (1-4), (2-1), (2-2) or (2-3) : wherein R and R1 each independently represent a hydrogen atom or a monovalent substituent, and when a plurality of R or R1 are present, they may be the same or different.

  本申请涉及一种由具有吲唑环结构的化合物和磷光发光化合物组成的组合物，其中具有吲唑环结构的化合物是一种聚合物，其重复单元是由通式（1-1）、（1-2）、（1-3）、（1-4）、（2-1）、（2-2）或（2-3）表示的吲唑环结构： 其中 R 和 R1 各自独立地代表氢原子或单价取代基，当存在多个 R 或 R1 时，它们可以相同或不同。
• DERIVATIVES OF AZAINDOLES AS INHIBITORS OF PROTEIN KINASES ABL AND SRC
  申请人：OriBase Pharma

  公开号：EP2396325B1

  公开（公告）日：2015-04-01