1,2-Epoxy-2-isopropyl-3-methylbutan | 23511-12-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环丁烷
• 英文名称: 1,2-Epoxy-2-isopropyl-3-methylbutan
• 英文别名: 2,2-Bis-isopropyl oxirane；2,2-Di(propan-2-yl)oxirane
• CAS: 23511-12-8
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: CBDQRNWHULYCPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY
  申请人：Tamura Yuusuke

  公开号：US20120015961A1

  公开（公告）日：2012-01-19

  The present invention provides, for example, a compound of the following formula (I): wherein R 1 is substituted amino and the like, R 2 is halogen and the like, R 3 is substituted or unsubstituted lower alkyl and the like, R A and R B are each independently hydrogen, substituted or unsubstituted lower alkyl and the like, R C and R D are each independently hydrogen, substituted or unsubstituted lower alkyl, or R C and R D together with the carbon atom to which they are attached may form a substituted or unsubstituted carbocycle, and ring A is a carbocycle or a heterocycle, its pharmaceutically acceptable salt, or a solvate thereof as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-βproteins.

  本发明提供了以下式（I）的化合物，例如： 其中R 1 是取代氨基等， R 2 是卤素等， R 3 是取代或未取代的较低烷基等， R A 和R B 各自独立地是氢、取代或未取代的较低烷基等， R C 和R D 各自独立地是氢、取代或未取代的较低烷基，或R C 和R D 与它们连接的碳原子一起可以形成取代或未取代的碳环，以及 环A是碳环或杂环， 其药学上可接受的盐，或其溶剂合物作为由淀粉样蛋白β的产生、分泌和/或沉积引起的疾病的治疗剂。
• AMINOTHIAZINE OR AMINOOXAZINE DERIVATIVE HAVING AMINO LINKER
  申请人：Masui Moriyasu

  公开号：US20120238557A1

  公开（公告）日：2012-09-20

  The present invention provide a medicament for treating the diseases induced by production, secretion or deposition of amyloid-β proteins, for example, a compound of the following formula (I) wherein R 1 , R 2a , R 2b , R 3 , R 4 , R 5 , X, L 1 , L 2 , A, ring B and the dotted line are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.

  本发明提供了一种治疗由淀粉样蛋白β的产生、分泌或沉积引起的疾病的药物，例如以下式(I)的化合物，其中R1、R2a、R2b、R3、R4、R5、X、L1、L2、A、环B和虚线在规范中有定义，其药学上可接受的盐或溶剂化合物。
• FUSED HETEROCYCLIC COMPOUND HAVING AMINO GROUP
  申请人：Yoshida Syuhei

  公开号：US20120245155A1

  公开（公告）日：2012-09-27

  The present invention provides, for example, a compound mentioned below as a medicament for treating or preventing the diseases induced by production, secretion or deposition of amyloid-βproteins. A compound of the formula (I): wherein R 1 , R 2a , R 2b , R 3 , R 4 , R 5a , R 5b , R 6a , R 6b , X, Y, Z, ring A and the dashed lines are defined in the specification, its pharmaceutically acceptable salt or a solvate thereof.

  本发明提供了一个如下所述的化合物作为治疗或预防由淀粉样β蛋白的产生、分泌或沉积引起的疾病的药物。式（I）的化合物：其中R1、R2a、R2b、R3、R4、R5a、R5b、R6a、R6b、X、Y、Z、环A和虚线在说明书中定义，其药用可接受的盐或其溶剂化合物。
• HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：US20170240512A1

  公开（公告）日：2017-08-24

  The present invention relates to a compound represented by Formula (I): wherein -L- is —C(═X)—, or the like, —Z— is —NR 5 —, or the like, —Z A — is —NR 5A —, or the like, —W— is —C(R 8 R 9 )n-, —W A — is —C(R 3 R 4 )m-, B is substituted or unsubstituted aromatic carbocyclyl, or the like, Y is a bond, or the like, the ring C is a substituted or unsubstituted aromatic heterocycle, or the like, R 2 is a hydrogen atom, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

  本发明涉及一种由式（I）表示的化合物：其中-L-为—C(═X)—，或类似的，—Z—为—NR5—，或类似的，—ZA—为—NR5A—，或类似的，—W—为—C(R8R9)n-，—WA—为—C(R3R4)m-，B为取代或未取代的芳香环烃基，或类似的，Y为键，或类似的，环C为取代或未取代的芳香杂环，或类似的，R2为氢原子，或类似的，或其药学上可接受的盐，或包括其的药物组成。
• FUSED AMINODIHYDROPYRIMIDINE DERIVATIVE
  申请人：Masui Moriyasu

  公开号：US20130210839A1

  公开（公告）日：2013-08-15

  The present invention provides, for example, the following compound: wherein ring A is a substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, X 1 —X 2 ═X 3 is CR 5 —CR 6 ═CR 7 , N—CR 6 ═CR 7 , CR 5 —N═CR 7 or CR 5 —CR 6 ═N, R 1 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, R 2a and R 2b are each independently hydrogen, substituted or unsubstituted alkyl or the like, R 4a , R 4b , R 5 , R 6 and R 7 are each independently hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl or the like, its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid β production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid β proteins.

  本发明提供了如下化合物：其中环A是取代或未取代的碳环或取代或未取代的杂环，X1—X2═X3为CR5—CR6═CR7，N—CR6═CR7，CR5—N═CR7或CR5—CR6═N，R1为取代或未取代的烷基，取代或未取代的烯基等，R2a和R2b各自独立为氢，取代或未取代的烷基等，R4a，R4b，R5，R6和R7各自独立为氢，卤素，羟基，取代或未取代的烷基等，其药学上可接受的盐或其溶剂化合物具有抑制淀粉样蛋白β产生的作用，特别是BACE1抑制活性，并可用作治疗由淀粉样蛋白β蛋白产生、分泌或沉积引起的疾病的药物。