5-(dimethylamino)methyl-2-(methylthio)methylfuran | 19260-81-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-(dimethylamino)methyl-2-(methylthio)methylfuran
• 英文别名: N,N-dimethyl-1-[5-(methylsulfanylmethyl)furan-2-yl]methanamine
• CAS: 19260-81-2
• 化学式: C₉H₁₅NOS
• 分子量: 185.29
• InChiKey: YKCYYOHIFUDRAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  41.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-(dimethyamino)methyl-2-S-isothioureylmethylfuran dihydrochloride 、 碘甲烷 在 氢氧化钾 作用下， 生成 5-(dimethylamino)methyl-2-(methylthio)methylfuran
  参考文献：
  名称：

  Sega, Alessandro; Moimas, Flavio; Decorte, Enio, Gazzetta Chimica Italiana, 1982, vol. 112, # 9/10, p. 421 - 428

  摘要：

  DOI：

文献信息

• Pyrimidone compounds, their preparation, and pharmaceutical compositions containing them
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0086647A2

  公开（公告）日：1983-08-24

  Novel pyrimidones of the formula I and salts thereof are gastric acid secretion inhibitors and some have other medical utility: wherein R1 represents a hydrogen atom, a C1 to C10 alkyl group, a C1 to C5 alkenyl group, a C1 to C5 alkinyl group, a phenyl group, a cycloalkylmethyl group, an unsubstituted or R3 substituted aralkyl group, or the group -A-N wherein A R4 represents a C1 to C5 alkylene group and R3 and R4 are the same or different C1 to C5 alkyl groups or combine to form with the adjacent nitrogen atom a piperidine or pyrrolidine ring; R2 represents a hydrogen atom, a C1 to C5 alkyl group or a trifluoromethyl group; Y represents a heterocyclic group of the formula: or wherein R represents a hydrogen atom or a C1 to C5 alkyl group; B represents an oxygen atom or a sulfur atom; m represents zero or an integer of 1 to 3; and n represents an integer of 1 to 3. Methods and novel intermediates for their preparation are disclosed, as well as medicaments containing them and medical treatments using them.

  式 I 的新型嘧啶酮及其盐类是胃酸分泌抑制剂，有些还具有其他医疗用途： 其中 R1 代表氢原子、C1 至 C10 烷基、C1 至 C5 烯基、C1 至 C5 烷基、苯基、环烷基甲基、未取代或 R3 取代的芳基，或基团 -A-N 其中 A R4 代表 C1 至 C5 亚烷基，R3 和 R4 是相同或不同的 C1 至 C5 烷基，或与相邻的氮原子结合形成哌啶或吡咯烷环；R2 代表氢原子、C1 至 C5 烷基或三氟甲基； Y 代表式中的杂环基团： 或 其中R代表氢原子或C1至C5烷基；B代表氧原子或硫原子；m代表零或1至3的整数；n代表1至3的整数。 本发明公开了用于制备它们的方法和新型中间体，以及含有它们的药物和使用它们的医疗方法。
• NOVEL ION EXCHANGE POROUS RESINS FOR SOLID PHASE EXTRACTION AND CHROMATOGRAPHY
  申请人：LEE Peter Jeng Jong

  公开号：US20100324159A1

  公开（公告）日：2010-12-23

  Embodiments of the present invention are directed to porous resins for solid phase extractions. The resins feature at least one hydrophobic component, at least one hydrophilic component and at least one ion exchange functional group. The resins exhibit superior wetting and ion exchange performance.