N-{3-cyano-6-[3-(4-methoxy-6-methyl-pyridin-2-yl)-propanoyl]-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl}-3-(2,5-dimethoxy-phenyl)-propionamide | 916237-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-{3-cyano-6-[3-(4-methoxy-6-methyl-pyridin-2-yl)-propanoyl]-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl}-3-(2,5-dimethoxy-phenyl)-propionamide
• 英文别名: N-[3-cyano-6-[3-(4-methoxy-6-methylpyridin-2-yl)propanoyl]-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-3-(2,5-dimethoxyphenyl)propanamide
• CAS: 916237-78-0
• 化学式: C₂₉H₃₂N₄O₅S
• 分子量: 548.663
• InChiKey: UOQONTXEAPCYPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  142
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Novel Tetrahydropyridothiophenes
  申请人：Pekari Klaus

  公开号：US20080260749A1

  公开（公告）日：2008-10-23

  Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

  具有某种化学式（I）的化合物，在其中Ra和Rb具有描述中指示的含义，是具有抗增殖和诱导凋亡活性的新型有效化合物。
• ANTI-VIRAL COMPOUNDS
  申请人：Rockway W. Todd

  公开号：US20070232645A1

  公开（公告）日：2007-10-04

  Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

  本发明揭示了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。本发明还涉及包含这种化合物的组合物、与其他抗病毒或治疗剂一起配方或共同管理这种化合物的组合物、用于合成这种化合物的过程和中间体，以及使用这种化合物治疗HCV或其他病毒感染的方法。
• NOVEL TETRAHYDROPYRIDOTHIOPHENES
  申请人：Pekari Klaus

  公开号：US20090257977A1

  公开（公告）日：2009-10-15

  Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.

  某一公式（I）的化合物，其中Ra和Rb的含义如说明书所示，是具有抗增殖和诱导细胞凋亡活性的新型有效化合物。
• Anti-Viral Compounds
  申请人：Rockway Todd W.

  公开号：US20100256139A1

  公开（公告）日：2010-10-07

  Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

  本发明揭示了一些有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。本发明还涉及包含这些化合物的组合物，这些化合物与其他抗病毒或治疗剂的联合制剂或联合给药，用于合成这些化合物的过程和中间体，以及使用这些化合物治疗HCV或其他病毒感染的方法。
• TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER
  申请人：Nycomed GmbH

  公开号：EP1893618A2

  公开（公告）日：2008-03-05