4-{[2-(3-Methylphenyl)quinazolin-4-yl]amino}phenol | 384359-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-{[2-(3-Methylphenyl)quinazolin-4-yl]amino}phenol
• 英文别名: 4-[[2-(3-methylphenyl)quinazolin-4-yl]amino]phenol
• CAS: 384359-93-7
• 化学式: C₂₁H₁₇N₃O
• mdl: MFCD02959123
• 分子量: 327.4
• InChiKey: UQNNTLJQMUOLIR-UHFFFAOYSA-N

物化性质

• 沸点：
  446.8±45.0 °C(Predicted)
• 密度：
  1.278±0.06 g/cm3(Predicted)
• 溶解度：
  5.8 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  58
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Sheridan Joseph M.

  公开号：US20140031547A1

  公开（公告）日：2014-01-30

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.
• CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES
  申请人：Electrophoretics Limited

  公开号：US20160354375A1

  公开（公告）日：2016-12-08

  The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (CK1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as Alzheimer's disease.