1-methyl-3-(trifluoromethyl)-6-(3-(trifluoromethyl)phenyl)quinoxalin-2(1H)-one | 1225319-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-methyl-3-(trifluoromethyl)-6-(3-(trifluoromethyl)phenyl)quinoxalin-2(1H)-one
• 英文别名: 1-Methyl-3-(trifluoromethyl)-6-[3-(trifluoromethyl)phenyl]quinoxalin-2-one
• CAS: 1225319-62-9
• 化学式: C₁₇H₁₀F₆N₂O
• 分子量: 372.27
• InChiKey: AYIWHOOQRDPKSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION
  申请人：BARTOLOZZI Alessandra

  公开号：US20130196967A1

  公开（公告）日：2013-08-01

  The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R 1 -R 7 , A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

  本发明涉及式(I)的化合物： 或其药用可接受的盐，其中R1-R7、A和HET按本文定义。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和失调的方法，以及制备这些化合物和在这些过程中有用的中间体的方法。
• SUBSTITUTED HETEROCYCLIC COMPOUNDS
  申请人：Koltun Dmitry

  公开号：US20100113461A1

  公开（公告）日：2010-05-06

  The present invention relates to compounds that are late sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein R 1 , R 2 , R 3 , and R 4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

  本发明涉及晚钠通道抑制剂化合物及其在治疗各种疾病状态中的应用，包括心血管疾病和糖尿病。特别是，在某些实施例中，化合物的结构由公式（I）给出：其中R1，R2，R3和R4如本文所述，以及制备和使用该化合物的方法以及含有该化合物的药物组合物。
• US8912190B2
  申请人：——

  公开号：US8912190B2

  公开（公告）日：2014-12-16
• US9174980B2
  申请人：——

  公开号：US9174980B2

  公开（公告）日：2015-11-03
• [EN] 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL<br/>[FR] INHIBITEURS, À BASE DE 2-OXOQUINOXALINE, DES CANAUX SODIQUES TARDIFS
  申请人：GILEAD PALO ALTO INC

  公开号：WO2010053757A1

  公开（公告）日：2010-05-14

  The present invention relates to compounds that are late sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I) wherein R1, R2, R3, and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.