5-Bromo-8-(4-morpholinylsulfonyl)isoquinoline | 862777-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-Bromo-8-(4-morpholinylsulfonyl)isoquinoline
• 英文别名: 4-(5-bromoisoquinolin-8-yl)sulfonylmorpholine
• CAS: 862777-70-6
• 化学式: C₁₃H₁₃BrN₂O₃S
• 分子量: 357.22
• InChiKey: JVMIVPXGCPLJQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
  申请人：Allen Patrick Martin

  公开号：US20050182079A1

  公开（公告）日：2005-08-18

  The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.

  本发明涉及作为有效的磷酸二酯酶（PDE）抑制剂的取代喹唑啉和异喹啉化合物。特别是，本发明涉及作为PDE-10的选择性抑制剂的上述化合物。本发明还涉及用于制备所述化合物的中间体；包含所述化合物的药物组合物；以及使用所述化合物在治疗某些中枢神经系统（CNS）或其他疾病的方法。
• TETRAHYDROISOQUINOLINYL DERIVATIVES OF QUINAZOLINE AND ISOQUINOLINE
  申请人：Pfizer Products Incorporated

  公开号：EP1723134A2

  公开（公告）日：2006-11-22
• US7268142B2
  申请人：——

  公开号：US7268142B2

  公开（公告）日：2007-09-11
• [EN] TETRAHYDROISOQUINOLINYL DERIVATIVES OF QUINAZOLINE AND ISOQUINOLINE<br/>[FR] DERIVES TETRAHYDROISOQUINOLINYLIQUES DE QUINAZOLINE ET D'ISOQUINOLINE
  申请人：PFIZER PROD INC

  公开号：WO2005082883A2

  公开（公告）日：2005-09-09

  The invention pertains to substituted quinazoline and isoquinoline of formula (I) that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders. or a pharmaceutically acceptable salt, solvate or prodrug thereof.