7,8-dihydroxy-4-(2-imidazolinyl)chroman hydrobromide | 102535-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 7,8-dihydroxy-4-(2-imidazolinyl)chroman hydrobromide
• CAS: 102535-60-4
• 化学式: BrH*C₁₂H₁₄N₂O₃
• 分子量: 315.167
• InChiKey: ZTBCVQOZIQMPSA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  7,8-dimethoxy-4-(2-imidazolinyl)chroman hydrochloride 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以59%的产率得到7,8-dihydroxy-4-(2-imidazolinyl)chroman hydrobromide
  参考文献：
  名称：

  Conformationally defined adrenergic agents. 3. Modifications to the carbocyclic ring of 5,6-dihydroxy-1-(2-imidazolinyl)tetralin: improved separation of .alpha.1 and .alpha.2 adrenergic activities

  摘要：

  A series of modifications to positions 1, 2, and 4 of the tetralin ring of 5,6-dihydroxy-1-(2-imidazolinyl)tetralin (1, A-54741) succeeded in improving the separation of the potent alpha 1 and alpha 2 adrenergic agonism observed for the parent compound 1. In particular 5,6-dihydroxy-4,4-dimethyl-1-(2-imidazolinyl)tetralin (7) was found to be a specific alpha 1 adrenergic agonist, and 7,8-dihydroxy-4-(2-imidazolinyl)chroman (2) was found to have improved alpha 2 adrenergic agonistic selectivity relative to the parent compound 1.

  DOI：

  10.1021/jm00158a016