(R,S)-2-bromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester | 1056159-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: (R,S)-2-bromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester
• 英文别名: 2-Bromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester；ethyl 2-bromo-4-methyl-4,5,7,8-tetrahydrothieno[2,3-d]azepine-6-carboxylate
• CAS: 1056159-41-1
• 化学式: C₁₂H₁₆BrNO₂S
• 分子量: 318.235
• InChiKey: OQYAFLAWYGQXFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  57.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R,S)-2-bromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester 、 三甲基乙酰氯 在 正丁基锂 、 氢氧化钾 、 sodium hydroxide 、 乙醇 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 生成 (R,S)-2,2-dimethyl-1-(4-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-2-yl)-propan-1-one
  参考文献：
  名称：

  WO2007/84622

  摘要：

  公开号：
• 作为产物：
  描述：

  4-Methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester 在 N-溴代丁二酰亚胺(NBS) 、 溶剂黄146 作用下， 以 氯仿 为溶剂， 反应 0.25h， 生成 (R,S)-2-bromo-4-methyl-4,5,7,8-tetrahydro-thieno[2,3-d]azepine-6-carboxylic acid ethyl ester
  参考文献：
  名称：

  WO2007/84622

  摘要：

  公开号：

文献信息

• Substituted azepine derivatives as serotonin receptor modulators
  申请人：Bennani L. Youssef

  公开号：US20060003990A1

  公开（公告）日：2006-01-05

  The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

  本发明一般涉及一系列化合物，含有这些化合物的药物组合物，以及将这些化合物和组合物用作治疗剂。更具体地，本发明的化合物是六氢吲哚和八氢吲哚化合物。这些化合物是5-羟色胺受体（5-HT）配体，可用于治疗需要调节5-羟色胺受体（5-HT）活性的疾病、障碍和症状（例如焦虑、抑郁和肥胖）。
• Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof
  申请人：Tumey Nathan L.

  公开号：US20070191342A1

  公开（公告）日：2007-08-16

  The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT 2c ) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT 2c ) is desired (e.g. addiction, anxiety, depression, obesity, and others).

  本发明通常涉及一系列化合物，包括含有这些化合物的药物组合物，以及将这些化合物和组合物用作治疗剂。更具体地说，本发明的化合物是噻吩基和吡咯基的戊氮平化合物。这些化合物是血清素受体（5-HT2c）配体，并且可用于治疗需要调节血清素受体（5-HT2c）活性的疾病、失调和情况（例如成瘾、焦虑、抑郁、肥胖和其他疾病）。
• Substituted Azepine Derivatives As Serotonin Receptor Modulators
  申请人：Bennani Youssef L.

  公开号：US20100190772A1

  公开（公告）日：2010-07-29

  The present invention generally relates to compounds and pharmaceutical compositions containing the compounds. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

  本发明通常涉及化合物和含有这些化合物的药物组合物。更具体地说，本发明的化合物是六氢吲哚并环己氮化吲哚和八氢吲哚并环己氮化吲哚化合物。这些化合物是血清素受体(5-HT)配体，可用于治疗希望调节血清素受体(5-HT)活性的疾病、障碍和病况(例如焦虑、抑郁和肥胖症)。
• THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF
  申请人：Tumey L. Nathan

  公开号：US20110112072A1

  公开（公告）日：2011-05-12

  The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT 2c ) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT 2c ) is desired (e.g. addiction, anxiety, depression, obesity, and others).

  本发明一般涉及一系列化合物，含有这些化合物的药物组合物，以及这些化合物和组合物作为治疗剂的用途。更具体地说，本发明的化合物是噻吩基和吡咯基的氮杂环庚烷化合物。这些化合物是血清素受体（5-HT2c）配体，并且对于治疗需要调节血清素受体（5-HT2c）活性的疾病，疾患和情况（例如成瘾，焦虑，抑郁，肥胖等）非常有用。
• C-MET PROTEIN KINASE INHIBITORS
  申请人：Lauffer David

  公开号：US20110136789A1

  公开（公告）日：2011-06-09

  The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.

  本发明涉及一种公式I的化合物，可用于抑制c-Met蛋白激酶。本发明还提供了包含该发明化合物的药学上可接受的组合物，并提供了使用该组合物治疗增殖性疾病的方法。