| 1314044-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1314044-03-5
• 化学式: Br*C₃₄H₃₇N₃O₅P
• 分子量: 678.563
• InChiKey: AVFZNFGVFDAXHV-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 三甲基溴硅烷 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以97%的产率得到
  参考文献：
  名称：

  Phosphonate–Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic–Therapeutic Nanoprobes

  摘要：

  Multimodal imaging-therapeutic nanoprobe TiO2@RhdGd was prepared and successfully used for in vitro and in vivo cell tracking as well as for killing of cancer cells in vitro. TiO2 nanoparticles were used as a core for phosphonic acid modified functionalities, responsible for contrast in MRI and optical imaging. The probe shows high H-1 relaxivity and relaxivity density values. Presence of fluorescent dye allows for visualization by means of fluorescence microscopy. The applicability of the probe was studied, using mesenchymal stem cells, cancer HeLa cells, and T-lymphocytes. The probe did not exhibit toxicity in any of these systems. Labeled cells were successfully visualized in vitro by means of fluorescence microscopy and MR.-Furthermore, it was shown that the probe TiO2@RhdGd can be changed into a cancer cell killer upon UV light irradiation. The above stated results represent a valuable proof of a principle showing applicability of the probe design for diagnosis and therapy.

  DOI：

  10.1021/jm200449y