1-Acetyl-3-methyl-2,3-dihydro-4(1H)-chinazolinon | 20865-98-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-Acetyl-3-methyl-2,3-dihydro-4(1H)-chinazolinon
• 英文别名: 1-acetyl-3-methyl-2,3-dihydro-1H-quinazolin-4-one；1-acetyl-3-methyl-2H-quinazolin-4-one
• CAS: 20865-98-9
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: VLKWUXJAAMGBLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Therapeutic agent for overactive bladder involved in aging
  申请人：Yokoyama Osamu

  公开号：US20060135507A1

  公开（公告）日：2006-06-22

  A method for treating overactive bladder involved in aging, comprising administrating a compound having a cholinesterase inhibitory activity, a pharmacologically acceptable salt or a solvate thereof to a patient with the overactive bladder involved in aging.

  一种治疗老年人过度活跃膀胱的方法，包括向患有老年人过度活跃膀胱的患者施用具有胆碱酯酶抑制活性的化合物、药理学上可接受的盐或其溶剂。
• Therapeutic agent for overactive bladder resulting from cerebral infarction
  申请人：Yokoyama Osamu

  公开号：US20060172992A1

  公开（公告）日：2006-08-03

  An agent for treating overactive bladder resulting from cerebral infarction, comprising administrating a compound having a cholinesterase inhibitory activity or a pharmacologically acceptable salt thereof.

  一种用于治疗因脑梗死引起的过度活动膀胱的制剂，包括给予具有胆碱酯酶抑制活性或其药理学上可接受的盐的化合物。
• Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1764101A1

  公开（公告）日：2007-03-21

  A method of treating dementia caused by a vascular disease in a patient in need thereof comprising orally administering a therapeutically effective amount of donepezil or a pharmaceutically acceptable salt thereof.

  一种治疗有需要的患者因血管疾病引起的痴呆症的方法，包括口服治疗有效量的多奈哌齐或其药学上可接受的盐。
• NERVE REVENERATION PROMOTER
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1779867A1

  公开（公告）日：2007-05-02

  A nerve regeneration stimulator comprising a compound having a cholinesterase inhibitory activity, a pharmacologically acceptable salt thereof or a solvate thereof.

  一种神经再生刺激剂，包含一种具有胆碱酯酶抑制活性的化合物、其药理学上可接受的盐或其溶液。
• Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments associated with or caused by chemotherapy
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2140868A1

  公开（公告）日：2010-01-06

  The present invention relates to cholinesterase inhibitors such a donepezil for the treatment of cognitive impairments associated with or caused by chemotherapy

  本发明涉及用于治疗与化疗有关或由化疗引起的认知障碍的胆碱酯酶抑制剂，如多奈哌齐