The title compound 1 has been synthesized by utilizing some characteristic properties of (η 6 -arene)chromium complexes. The synthesis of dihydroxyserrulatic acid (1) consists of the following three key steps: (1) nucleophilic addition of a dithianyl group at the meta position to an electron-donating methoxy group, (2) trans arrangement of two benzylic substituents (at C-1 and C-4 positions), and (3)
利用(η 6 -
芳烃)
铬配合物的一些特性合成了标题化合物1。二羟基血清酸 (1) 的合成由以下三个关键步骤组成:(1) 在间位的二
噻吩基亲核加成到给电子的甲氧基,(2) 两个苄基取代基的反式排列(在 C- 1 和 C-4 位置),以及 (3) C-4 和 C-11 位置(环外位置)之间的立体控制。通过利用(
芳烃)
铬配合物,这三个步骤以高区域和立体选择性实现