N,N,N',N',-Tetrakis(2-hydroxypropyl)-1,4-diaminobutane | 104867-11-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N,N',N',-Tetrakis(2-hydroxypropyl)-1,4-diaminobutane
• 英文别名: 1-[4-[Bis(2-hydroxypropyl)amino]butyl-(2-hydroxypropyl)amino]propan-2-ol
• CAS: 104867-11-0
• 化学式: C₁₆H₃₆N₂O₄
• 分子量: 320.473
• InChiKey: BROWPQFCBZSVLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Macrophage stimulation by homolog or analog of quadrol
  申请人：The University of Akron

  公开号：EP0372123A1

  公开（公告）日：1990-06-13

  Quadrol and homologs and analogs thereof have been found to stimulate macrophage activity in warm blooded animals. As a consequence, these compounds may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol or a homolog or analog thereof may be applied topically, e.g., as the active agent in a wound dressing. The active compounds may be represented by the formula (I) wherein R₁ and R₂ are substituted alkyl (C₂-­C₆) in which the substituents include one or more hydroxyl groups attached to carbon atoms other than the alpha carbon atom, R₃ and R₄ are alkyl or substituted alkyl (C₁-C₆), and n=2 to about 6. Preferably R₁ through R₄ are the same and are 2-hydroxyalkyl.

  研究发现，Quadrol 及其同源物和类似物可刺激温血动物体内巨噬细胞的活性。因此，这些化合物可用于对抗细菌感染、清除退化组织和促进新组织生长。Quadrol 或其同源物或类似物可局部使用，例如作为伤口敷料中的活性剂。活性化合物可由式 (I) 表示 其中 R₁ 和 R₂ 是取代的烷基 (C₂-C₆)，其中取代基包括一个或多个连接到除α 碳原子以外的碳原子上的羟基，R₃ 和 R₄ 是烷基或取代的烷基 (C₁-C₆)，且 n=2 至约 6。R₁ 至 R₄ 最好是相同的 2-羟基烷基。
• DEVELOPER CARRIER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC DEVICE
  申请人：Canon Kabushiki Kaisha

  公开号：EP3683628A1

  公开（公告）日：2020-07-22

  Provided is a developer carrying member that enables stable formation of images of high quality even on recording paper having a high talc content. The developer carrying member includes a conductive base member and a surface layer, wherein the surface layer includes a urethane resin, and the urethane resin has a carbonate bond and a tertiary amine structure.

  本发明提供了一种即使在滑石粉含量较高的记录纸上也能稳定形成高质量图像的显影剂承载部件。显影剂承载部件包括导电基体和表面层，其中表面层包括聚氨酯树脂，聚氨酯树脂具有碳酸盐键和叔胺结构。
• Developer carrying member, process cartridge, and electrophotographic apparatus
  申请人：CANON KABUSHIKI KAISHA

  公开号：US11029622B2

  公开（公告）日：2021-06-08

  Provided is a developer carrying member that enables stable formation of images of high quality even on recording paper having a high talc content. The developer carrying member includes a conductive base member and a surface layer, wherein the surface layer includes a urethane resin, and the urethane resin has a carbonate bond and a tertiary amine structure.

  本发明提供了一种即使在滑石粉含量较高的记录纸上也能稳定形成高质量图像的显影剂承载部件。显影剂承载部件包括导电基体和表面层，其中表面层包括聚氨酯树脂，聚氨酯树脂具有碳酸盐键和叔胺结构。
• DEVELOPER CARRYING MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20200199402A1

  公开（公告）日：2020-06-25

  Provided is a developer carrying member that enables stable formation of images of high quality even on recording paper having a high talc content. The developer carrying member includes a conductive base member and a surface layer, wherein the surface layer includes a urethane resin, and the urethane resin has a carbonate bond and a tertiary amine structure.
• US4937269A
  申请人：——

  公开号：US4937269A

  公开（公告）日：1990-06-26