2-tert-Butylamino-1-pyridin-2-yl-ethanol | 78167-23-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-tert-Butylamino-1-pyridin-2-yl-ethanol
• 英文别名: 2-(Tert-butylamino)-1-pyridin-2-ylethanol
• CAS: 78167-23-4
• 化学式: C₁₁H₁₈N₂O
• 分子量: 194.277
• InChiKey: RTMXUVFCCAYLPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  45.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-tert-Butyl-2-hydroxy-2-(2-pyridyl)ethanamide 在 盐酸 、 dimethyl sulfide borane 作用下， 生成 2-tert-Butylamino-1-pyridin-2-yl-ethanol
  参考文献：
  名称：

  Modification of the Passerini reaction: facile synthesis of analogs of isoproterenol and (aryloxy)propanolamine .beta.-adrenergic blocking agents

  摘要：

  DOI：

  10.1021/jo00331a017

文献信息

• Beta adrenergic agonist and methods of using the same
  申请人：CURASEN THERAPEUTICS, INC.

  公开号：US10947196B2

  公开（公告）日：2021-03-16

  The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.

  本公开内容涉及化合物以及使用此类化合物治疗与肾上腺素能受体有关的疾病。
• BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME
  申请人：CURASEN THERAPEUTICS, INC.

  公开号：US20200308114A1

  公开（公告）日：2020-10-01

  The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.
• [EN] BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME<br/>[FR] AGONISTES BÊTA-ADRÉNERGIQUE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：CURASEN THERAPEUTICS INC

  公开号：WO2020198466A1

  公开（公告）日：2020-10-01

  The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. In certain embodiments of the methods disclosed herein, the methods include administering to the subject a compound as disclosed herein and a peripherally acting P-blocker (PABRA).