(Z)-12-(triethoxysilyl)-3,4,5,6,7,8,9,10,11,14,15,16,17,18,19,20,21,22-octadecahydrobenzo[c][1,6]dioxacyclohexacosine-1,24-dione | 758718-82-0

• 分子结构分类: 有机化合物
• 英文名称: (Z)-12-(triethoxysilyl)-3,4,5,6,7,8,9,10,11,14,15,16,17,18,19,20,21,22-octadecahydrobenzo[c][1,6]dioxacyclohexacosine-1,24-dione
• CAS: 758718-82-0
• 化学式: C₃₄H₅₆O₇Si
• 分子量: 604.9
• InChiKey: QNEMTHNIAQTGAA-KRUMMXJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.77
• 重原子数：
  42.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  80.29
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  (Z)-12-(triethoxysilyl)-3,4,5,6,7,8,9,10,11,14,15,16,17,18,19,20,21,22-octadecahydrobenzo[c][1,6]dioxacyclohexacosine-1,24-dione 在 silver fluoride 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 以90%的产率得到(E)-7,8,9,10,11,12,13,14,15,18,19,20,21,22,23,24,25,26-Octadecahydro-6,27-dioxa-benzocyclohexacosene-5,28-dione
  参考文献：
  名称：

  (E)-Cycloalkenes and (E,E)-cycloalkadienes by ring closing diyne- or enyne–yne metathesis/semi-reduction

  摘要：

  A concise, practical and stereoselective entry into macrocyclic (E)-alkenes is outlined comprising a sequence of ring closing alkyne metathesis (RCAM), trans-selective hydrosilylation of the resulting cycloalkynes catalyzed by [Cp*Ru(MeCN)(3)]PF6, and a protodesilylation of the ensuing vinylsilanes with AgF in aq. THF/MeOH. Moreover, the first examples of intramolecular enyne-yne metathesis reactions catalyzed by the Schrock alkylidyne complex (tBUO)(3)W drop CCMe3 are reported; the resulting cyclic enynes can be converted along similar lines into the corresponding (E,E)-configured 1,3-dienes in good overall yields. Cycloalkyne 4 and the (E)-configured cyclic olefins 6 and 21 were characterized by X-ray crystallography. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.05.042
• 作为产物：
  描述：

  Phthalic acid didodec-10-ynyl ester 在 Tris(t-butoxy)(2,2-dimethylpropylidyne)tungsten(VI), 98% Schrock Alkyne Metathesis Catalyst 、 tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 (Z)-12-(triethoxysilyl)-3,4,5,6,7,8,9,10,11,14,15,16,17,18,19,20,21,22-octadecahydrobenzo[c][1,6]dioxacyclohexacosine-1,24-dione
  参考文献：
  名称：

  (E)-Cycloalkenes and (E,E)-cycloalkadienes by ring closing diyne- or enyne–yne metathesis/semi-reduction

  摘要：

  A concise, practical and stereoselective entry into macrocyclic (E)-alkenes is outlined comprising a sequence of ring closing alkyne metathesis (RCAM), trans-selective hydrosilylation of the resulting cycloalkynes catalyzed by [Cp*Ru(MeCN)(3)]PF6, and a protodesilylation of the ensuing vinylsilanes with AgF in aq. THF/MeOH. Moreover, the first examples of intramolecular enyne-yne metathesis reactions catalyzed by the Schrock alkylidyne complex (tBUO)(3)W drop CCMe3 are reported; the resulting cyclic enynes can be converted along similar lines into the corresponding (E,E)-configured 1,3-dienes in good overall yields. Cycloalkyne 4 and the (E)-configured cyclic olefins 6 and 21 were characterized by X-ray crystallography. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.05.042