tris(hydroxymethyl)aminomethyl-hydrochloric acid | 333338-19-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tris(hydroxymethyl)aminomethyl-hydrochloric acid
• 英文别名: Tris-HCl；Tris(hydroxymethyl)aminoethane hydrochloride；2-(aminomethyl)-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
• CAS: 333338-19-5
• 化学式: C₅H₁₃NO₃*ClH
• 分子量: 171.624
• InChiKey: HYZDOKBFNBVDPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.67
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  86.7
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• PI3 KINASE/mTOR DUAL INHIBITOR
  申请人：Barda David Anthony

  公开号：US20120184577A1

  公开（公告）日：2012-07-19

  The present invention provides an imidazo[4,5-c]quinolin-2-one compound, or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.

  本发明提供了一种imidazo[4,5-c]quinolin-2-one化合物，或其药用可接受的盐，可以抑制PI3K和mTOR，因此在癌症治疗中具有用处。
• [EN] INHIBITOR OF JAK1 AND JAK2<br/>[FR] INHIBITEUR DE JAK1 ET JAK2
  申请人：LILLY CO ELI

  公开号：WO2013188184A1

  公开（公告）日：2013-12-19

  The present invention provides an amino pyrazole compound, which is 3-[(lR)-6-fluoro-2,3-dihydro-1H-inden-l-yl]-N-(3- methyl-IH- pyrazol-5-yl)-3H-imidazo[4,5-b]pyridin-5-amine, or a pharmaceutically acceptable salt thereof, that inhibits JAK1 and JAK2 and, therefore may be useful in treating cancer.

  本发明提供了一种氨基吡唑化合物，即3-[(lR)-6-氟-2,3-二氢-1H-茚-1-基]-N-(3-甲基-1H-吡唑-5-基)-3H-咪唑并[4,5-b]吡啶-5-胺，或其药学上可接受的盐，该化合物抑制JAK1和JAK2，因此可能在治疗癌症方面有用。
• [EN] IMIDAZO [4, 5 -C] QUINOLIN- 2 -ONE COMPOUND AND ITS USE AS PI3 KINASE / MTOR DUAL INHIBITOR<br/>[FR] COMPOSÉ D'IMIDAZO[4,5-C]QUINOLIN-2-ONE ET SON UTILISATION COMME INHIBITEUR DOUBLE DE KINASE PI3/MTOR
  申请人：LILLY CO ELI

  公开号：WO2012097039A1

  公开（公告）日：2012-07-19

  The present invention provides an imidazo[4,5-c]quinolin-2-one compound (formula (I)), or a pharmaceutically acceptable salt thereof, that inhibits both PI3K and mTOR and, therefore, is useful in the treatment of cancer.

  本发明提供一种咪唑[4,5-c]喹啉-2-酮化合物（式（I）），或其药学上可接受的盐，该化合物抑制PI3K和mTOR，因此在癌症治疗中有用。
• INHIBITOR OF JAK1 AND JAK2
  申请人：Eli Lilly and Company

  公开号：US20150133490A1

  公开（公告）日：2015-05-14

  The present invention provides an amino pyrazole compound, which is 3-[(1R)-6-fluoro-2,3-dihydro-1H-inden-1-yl]-N-(3-methyl-1H-pyrazol-5-yl)-3H-imidazo[4,5-b]pyridin-5-amine, or a pharmaceutically acceptable salt thereof, that inhibits JAK1 and JAK2 and, therefore may be useful in treating cancer.

  本发明提供了一种氨基吡唑化合物，即3-[(1R)-6-氟-2,3-二氢-1H-茚-1-基]-N-(3-甲基-1H-吡唑-5-基)-3H-咪唑并[4,5-b]吡啶-5-胺或其药学上可接受的盐，它可以抑制JAK1和JAK2，因此可能在治疗癌症方面有用。
• Analytical element and method for theophylline determination having increased alkaline phosphatase isoenzyme
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0258035A2

  公开（公告）日：1988-03-02

  Theophylline can be determined with an analytical element and method which utilize the inhibition, by theophylline, of alkaline phosphatase activity on an appropriate substrate. The assay is carried out at a pH of 9 or less. The element contains a suitable buffer and first and second zones in fluid contact. The isoenzyme of alkaline phosphatase and a suitable substrate for the isoenzyme are located in different zones of the element. The isoenzyme is present in one of the zones in an amount of at least 100 I.U./m². This level of isoenzyme reduces or eliminates bias caused by endogenous alkaline phosphatase and hemoglobin during an assay.

  茶碱可以用一种分析元素和方法来测定，这种元素和方法利用茶碱对适当底物上碱性磷酸酶活性的抑制作用。检测在 pH 值为 9 或更低的条件下进行。检测元件包含合适的缓冲液以及液体接触的第一区和第二区。碱性磷酸酶同工酶和该同工酶的适当底物位于该元件的不同区域。其中一个区中的同工酶含量至少为 100 I.U./m²。这种水平的同工酶可减少或消除化验过程中内源性碱性磷酸酶和血红蛋白造成的偏差。