(1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-formamide | 675126-11-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-formamide
• 英文别名: N-[(1R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide
• CAS: 675126-11-1
• 化学式: C₁₇H₁₅Cl₂NO
• 分子量: 320.218
• InChiKey: QTQHFJQQMCUQEY-YVEFUNNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1R,4S)-N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-formamide 在 盐酸 、 甲醇 、 水 作用下， 反应 3.0h， 以99.6%的产率得到
  参考文献：
  名称：

  WO2007/6003

  摘要：

  公开号：

文献信息

• TREATMENT OF PAIN DISORDERS WITH trans 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE AND ITS FORMAMIDE
  申请人：Tarantino Paul Michael

  公开号：US20070282007A1

  公开（公告）日：2007-12-06

  Treatment of pain disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro- 1 -napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful in treatment of pain disorders.

  使用(1R,4S)-反式-4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺和(1S,4R)-反式-4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺治疗疼痛疾病。还公开了一种制备4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺的方法。该方法包括制备N-[4-(3,4-二氯苯基)-1,2,3,4-四氢萘-1-基]甲酰胺的所有四种异构体，这些异构体在治疗疼痛疾病中也有用。
• Processes for the Preparation of Dasotraline and Intermediates Thereof
  申请人：Apotex Inc.

  公开号：US20190194122A1

  公开（公告）日：2019-06-27

  The present invention provides processes for the preparation of Dasotraline (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (2), or a salt thereof, and its deprotection to afford Dasotraline (1).

  本发明提供了制备Dasotraline（1）的工艺，以及在制备中有用的中间体。具体而言，提供了用于生产化合物Formula（2）或其盐的工艺，以及其去保护以得到Dasotraline（1）的工艺。
• Treatment of CNS Disorders With trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine
  申请人：Jerussi Thomas P.

  公开号：US20090292026A1

  公开（公告）日：2009-11-26

  Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

  本发明公开了使用(1R,4S)-顺式4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺和(1S,4R)-顺式4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺治疗中枢神经系统疾病的方法。本发明还公开了制备4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺的方法。该方法包括制备所有四个N-[4-(3,4-二氯苯基)-1,2,3,4-四氢萘-1-基]甲酰胺的异构体，这些异构体也是有用的。
• Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
  申请人：SUNOVION PHARMACEUTICALS INC.

  公开号：US10328036B2

  公开（公告）日：2019-06-25

  Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

  公开了用(1R,4S)-反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺治疗中枢神经系统疾病；以及(1S,4R)-反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺。还公开了一种制备 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺的工艺。该工艺包括制备 N-[4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘基]甲酰胺的所有四种异构体，这些异构体也是有用的。
• Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide
  申请人：Jerussi P. Thomas

  公开号：US20060216799A1

  公开（公告）日：2006-09-28

  Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

  公开了用(1R,4S)-反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺治疗中枢神经系统疾病；以及(1S,4R)-反式 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺。还公开了一种制备 4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘胺的工艺。该工艺包括制备 N-[4-(3,4-二氯苯基)-1,2,3,4-四氢-1-萘基]甲酰胺的所有四种异构体，这些异构体也是有用的。