4-[2-(1,1-dimethyl-3-phenyl-1H-inden-5-yl)vinyl]-benzoic acid | 166977-69-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-[2-(1,1-dimethyl-3-phenyl-1H-inden-5-yl)vinyl]-benzoic acid
• 英文别名: 4-[(E)-2-(1,1-dimethyl-3-phenylinden-5-yl)ethenyl]benzoic acid
• CAS: 166977-69-1
• 化学式: C₂₆H₂₂O₂
• 分子量: 366.459
• InChiKey: SLYAIMIPLRTSPN-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl 4-[2-(1,1-dimethyl-3-phenyl-1H-inden-5-yl)-vinyl]benzoate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以90%的产率得到4-[2-(1,1-dimethyl-3-phenyl-1H-inden-5-yl)vinyl]-benzoic acid
  参考文献：
  名称：

  Retinoid-like compounds

  摘要：

  该发明涉及一种具有以下结构的化合物##STR1##或其无毒的药学上可接受的盐、生理可水解酯或溶剂化合物，其中X为--O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, --CH.sub.2 --NH--, --COCH.sub.2 --, --NHCS--, --CH.sub.2 S--, --CH.sub.2 O--, --OCH.sub.2 --, --NHCH.sub.2 --或--CR.sup.5 .dbd.CR.sup.6 --；R.sup.m和R.sup.k独立地为氢、卤素、C.sub.1-6烷基、羟基、C.sub.1-6烷氧基或硝基；n为零或一；R.sup.4为--(CH.sub.2).sub.t --Y、C.sub.1-6烷基或C.sub.3-6环烷基；R.sup.1为--CO.sub.2 Z、C.sub.1-6烷基、CH.sub.2 OH、--CONHR.sup.y或CHO；R.sup.2和R.sup.3独立地为氢或C.sub.1-6烷基；R.sup.a和R.sup.b独立地为氢或C.sub.1-6烷基；但当n为一时，R.sup.a和R.sup.b可以共同形成以下结构的基团##STR2##Y为萘基或苯基，两个基团可以选择性地用一个到三个相同或不同的C.sub.1-6烷基或卤素取代；Z为氢或C.sub.1-6烷基；R.sup.5、R.sup.6和R.sup.y独立地为氢或C.sub.1-6烷基；t为零到六。

  公开号：

  US05648385A1

文献信息

• HAIR TREATMENT COMPOSITION AND HAIR COSMETIC FOR DAMAGED HAIR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1602354A1

  公开（公告）日：2005-12-07

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。
• Cosmetic composition and production thereof
  申请人：Kawasaki Yuji

  公开号：US20060018867A1

  公开（公告）日：2006-01-26

  It has been desired to develop a highly preservative and antibacterial cosmetic composition that can easily be applied to both emulsion and non-emulsion type cosmetics. It has also been desired to develop a method of improving a preservative and/or antibacterial effect(s) of a cosmetic composition comprising polyorganosiloxane-containing epsilon-polylysine and thereby reducing the amount of antibacterial preservative agent to be used. There is provided a cosmetic composition comprising one or a combination of two or more of polyorganosiloxane-containing epsilon-polylysine compounds obtained by reacting epsilon-polylysine with polyorganosiloxane or a physiologically acceptable salt thereof, and polyhydric alcohol.

  人们一直希望开发一种高防腐性和抗菌性的化妆品组合物，这种组合物既可用于乳液型化妆品，也可用于非乳液型化妆品。此外，还希望开发一种方法，以改善含有聚有机硅氧烷的ε-聚赖氨酸的化妆品组合物的防腐和/或抗菌效果，从而减少抗菌防腐剂的用量。本发明提供了一种化妆品组合物，该组合物包含一种或两种以上的含聚有机硅氧烷的ε-聚赖氨酸化合物的组合，这些ε-聚赖氨酸化合物是通过ε-聚赖氨酸与聚有机硅氧烷或其生理上可接受的盐以及多元醇反应而得到的。
• Hair treatment composition and hair cosmetic for damaged hair
  申请人：Hasebe Kouhei

  公开号：US20060165636A1

  公开（公告）日：2006-07-27

  The present invention intends to provide a composition for hair treatment containing γ-polyglutamic acid or a salt thereof, a hair cosmetic for damaged hair containing such a composition, and their uses. The composition for hair treatment containing γ-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have excellent improvement effects on the strength and frictional force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and broken hair as well as improvements in combing and touch. Furthermore, they also exert effects of moisture retention inherent to γ-polyglutamic acid or a salt thereof, preventing or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of stickiness or creak, and various effectiveness including appropriate residual tendency to hair in a simultaneous manner, respectively.

  本发明旨在提供一种含有γ-聚谷氨酸或其盐的头发治疗组合物、一种含有这种组合物的用于受损头发的护发化妆品及其用途。本发明的含有γ-聚谷氨酸或其盐的头发治疗组合物和用于受损头发的护发化妆品对头发的强度和摩擦力有很好的改善效果，因此它们可以为受损头发提供张力、弹性等，以防止或减轻头发分叉和断裂，并改善梳理和触感。此外，它们还能分别发挥γ-聚谷氨酸或其盐固有的保湿效果、在此基础上防止或改善头皮屑产生的效果、防止粘腻感或吱吱作响的效果，以及包括同时对头发产生适当残留倾向在内的各种功效。
• Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0661259B1

  公开（公告）日：1997-10-08
• Use of polyglutamic acid or its salts
  申请人：Meiji Seika Kaisha Ltd.

  公开号：EP1602354B1

  公开（公告）日：2008-11-05