(Z)-2-(5-hydroxy-3,3-dimethyl-3,4-dihydro-(2H)-isoquinolin-1-ylidene)-1-phenylethan-1-one | 394651-20-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-2-(5-hydroxy-3,3-dimethyl-3,4-dihydro-(2H)-isoquinolin-1-ylidene)-1-phenylethan-1-one
• 英文别名: (2Z)-2-(5-hydroxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-ylidene)-1-phenylethanone
• CAS: 394651-20-8
• 化学式: C₁₉H₁₉NO₂
• 分子量: 293.365
• InChiKey: DZSAPSWKKAEOQC-WJDWOHSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
  申请人：Ohhata Akira

  公开号：US20050222138A1

  公开（公告）日：2005-10-06

  A nitrogen-containing bicyclic compound of formula (I) or a pharmaceutically acceptable salt thereof (wherein the symbols have the same meanings as described in the specification). The compound of formula (I) has an inhibitory activity against PDE7 and it is useful for the prevention and/or treatment of various diseases, i.e. autoimmune diseases (ulcerative colitis, Crohn's disease, rheumatism, psoriasis, multiple sclerosis, collagenosis, etc.), inflammatory diseases (obstructive pulmonary disease, sepsis, pancreatitis, sarcoidosis, nephritis, hepatitis, enteritis, etc.), allergic diseases (asthma, allergic rhinitis, allergic conjunctivitis, seasonal conjunctivitis, atopic dermatitis, etc.), rejection of organ transplants, serious graft versus host disease (GVHD), diabetic disease, osteoporosis, bone fracture, restenosis, atherosclerosis, obesity, ischemic reperfusion injury, depression, Parkinson's disease, dementia, leukemia, etc.

  化学式（I）的含氮双环化合物或其药用盐（其中符号的含义与说明书中描述的相同）。 化合物的化学式（I）具有对PDE7的抑制活性，对于预防和/或治疗各种疾病非常有用，即自身免疫性疾病（溃疡性结肠炎、克罗恩病、风湿病、牛皮癣、多发性硬化症、结缔组织病等）、炎症性疾病（慢性阻塞性肺病、败血症、胰腺炎、结节病、肾炎、肝炎、肠炎等）、过敏性疾病（哮喘、过敏性鼻炎、过敏性结膜炎、季节性结膜炎、特应性皮炎等）、器官移植排斥、严重移植物抗宿主病（GVHD）、糖尿病、骨质疏松症、骨折、再狭窄、动脉粥样硬化、肥胖症、缺血再灌注损伤、抑郁症、帕金森病、痴呆症、白血病等。
• 3,4 Dihydroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient
  申请人：——

  公开号：US20040077643A1

  公开（公告）日：2004-04-22

  A 3,4-dihydroisoquinoline derivative compound of formula (I) or a non-toxic salt thereof and a pharmaceutical agent comprising it as active ingredient (wherein all symbols have the same meaning as described in the specification). The compound of formula (I) has agonizing activity on CB2 receptor and therefore it is useful for the prophilaxis and/or treatment of various diseases such as asthma, nasal allergy, atopic dermatitis, autoimmune diseases, rheumatoid arthritis, immune dysfunction, postoperative pain, carcinomatous pain, etc. 1

  公式（I）的3,4-二氢异喹啉衍生物化合物或其无毒盐，以及包含其作为活性成分的药物剂。公式（I）的化合物对CB2受体具有激动活性，因此对于预防和/或治疗哮喘、鼻过敏、特应性皮炎、自身免疫疾病、类风湿关节炎、免疫功能障碍、术后疼痛、癌症性疼痛等多种疾病是有用的。
• 3,4-DIHYDROISOQUINOLINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1306373A1

  公开（公告）日：2003-05-02

  A 3,4-dihydroisoquinoline derivative compound of formula (I) or a non-toxic salt thereof and a pharmaceutical agent comprising it as active ingredient (wherein all symbols have the same meaning as described in the specification). The compound of formula (I) has agonizing activity on CB2 receptor and therefore it is useful for the prophilaxis and/or treatment of various diseases such as asthma, nasal allergy, atopic dermatitis, autoimmune diseases, rheumatoid arthritis, immune dysfunction, postoperative pain, carcinomatous pain, etc.

  一种式（I）的 3,4-二氢异喹啉衍生物化合物或其无毒盐，以及以其为活性成分的药物制剂（其中所有符号的含义与说明书所述相同）。式（I）化合物对 CB2 受体具有激动活性，因此可用于预防和/或治疗各种疾病，如哮喘、鼻过敏、特应性皮炎、自身免疫性疾病、类风湿性关节炎、免疫功能障碍、术后疼痛、癌性疼痛等。
• US6956033B2
  申请人：——

  公开号：US6956033B2

  公开（公告）日：2005-10-18
• US7378428B2
  申请人：——

  公开号：US7378428B2

  公开（公告）日：2008-05-27