24-Hydroxycholecalciferol | 58239-34-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-Hydroxycholecalciferol
• 英文别名: (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
• CAS: 58239-34-2
• 化学式: C₂₇H₄₄O₂
• 分子量: 400.6
• InChiKey: SNOXQOOPUCMFPS-ZLNGONTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Composition for solid pharmaceutical preparations of active vitamins D3 and process for preparation thereof
  申请人：TEIJIN LIMITED

  公开号：EP0116755A1

  公开（公告）日：1984-08-29

  This invention is concerned with a composition for solid pharmaceutical preparations of active vitamins D3, having the remarkably improved stability of active vitamins D3. and an extremely advantageous process for the preparation thereof from the industrial viewpoint. The composition of this invention is a composition for solid pharmaceutical preparations of active vitamins D3 prepared by forming an outer layer comprising active vitamins D3 and an excipient, which is readily soluble in an organic solvent, around an inner layer comprising an excipient which is slightly soluble in an organic solvent.

  本发明涉及一种活性维生素 D3 固体药物制剂组合物，其活性维生素 D3 的稳定性显著提高。本发明的组合物是一种用于活性维生素 D3 固体药物制剂的组合物，其制备方法是在由活性维生素 D3 和赋形剂（易溶于有机溶剂）组成的外层和由微溶于有机溶剂的赋形剂组成的内层周围形成一个外层。
• Pharmaceutical composition for external use containing active type vitam D3
  申请人：TEIJIN LIMITED

  公开号：EP0177920A2

  公开（公告）日：1986-04-16

  A pharmaceutical composition for external application to the skin of a warm-blooded animal comprising (A) a pharmaceutically effective amount of an active-type vitamin D3, and (B) a substantially water-free carrier containing the active-type vitamin D3 dissolved or uniformly dispersed therein.

  一种用于温血动物皮肤外用的药物组合物，包括 (A) 有效药用量的活性型维生素 D3，和 (B) 基本不含水的载体，其中含有溶解或均匀分散的活性型维生素 D3。
• Composition for injection of active type vitamins D3
  申请人：TEIJIN LIMITED

  公开号：EP0215596A2

  公开（公告）日：1987-03-25

  A composition for the injection of active type vitamins D₃ comprising a lyophilized product of active type vitamins D₃ and an excipient. This composition has good stability of active type vitamins D₃ and is effective as an injection preparation. This composition can be easily prepared.

  一种用于注射活性维生素 D₃ 的组合物，由活性维生素 D₃ 的冻干产品和赋形剂组成。 这种组合物具有良好的活性维生素 D₃ 稳定性，作为注射制剂效果显著。 这种组合物易于制备。
• SOLID PREPARATION OF ACTIVE VITAMIN D3 HAVING IMPROVED STABILITY
  申请人：TEIJIN LIMITED

  公开号：EP0413828A1

  公开（公告）日：1991-02-27

  This invention relates to a stabilized solid preparation of activated vitamin D3 comprising an activated D3 composition dispersed in an excipient which is readily soluble in an organic solvent and a basic substance such as sodium citrate or magnesium oxide.

  本发明涉及一种稳定的活性维生素 D3 固体制剂，包括分散在易溶于有机溶剂的赋形剂和柠檬酸钠或氧化镁等碱性物质中的活性维生素 D3 组合物。
• Stabilized pharmaceutical compositions containing derivatives of vitamins D2 and D3
  申请人：TEVA PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP0588539A1

  公开（公告）日：1994-03-23

  1. A solid state pharmaceutical composition which comprises at least ingredients (a), (b) and (c) of the following ingredients (a), (b), (c) and (d), namely: (a) at least one active component selected from pharmaceutically active derivatives of vitamin D2 and vitamin D3; (b) at least one pharmaceutically acceptable antioxidant; (c) at least one pharmaceutically acceptable polyoxyalkyl stabilizer; (d) at least one solid pharmaceutical excipient or carrier in an amount sufficient to impart the characteristics of a solid to the composition.

  1.一种固态药物组合物，它至少包含以下成分（a）、（b）、（c）和（d），即： 1： (a) 至少一种活性成分，选自维生素 D2 和维生素 D3 的药学活性衍生物； (b) 至少一种药学上可接受的抗氧化剂； (c) 至少一种药学上可接受的聚氧烷基稳定剂； (d) 至少一种固体药用赋形剂或载体，其用量足以使组合物具有固体的特性。