3-萘-1-基吡啶-4-甲腈 | 570396-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 3-萘-1-基吡啶-4-甲腈
• 英文名称: 4-Pyridinecarbonitrile, 3-(1-naphthalenyl)-
• 英文别名: 3-naphthalen-1-ylpyridine-4-carbonitrile
• CAS: 570396-89-3
• 化学式: C₁₆H₁₀N₂
• 分子量: 230.269
• InChiKey: JUZAZURXDNVQKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-萘-1-基吡啶-4-甲腈 在 盐酸 、 1-氯乙基氯甲酸酯 、 sodium cyanoborohydride 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成 1-(2-Amino-acetyl)-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile
  参考文献：
  名称：

  Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

  摘要：

  Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00095-7
• 作为产物：
  描述：

  4-氰基吡啶 N-氧化物 在 五氯化磷 、 三氯氧磷 作用下， 生成 3-萘-1-基吡啶-4-甲腈
  参考文献：
  名称：

  Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

  摘要：

  Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00095-7