N-methyl-N'-[4-(cholest-5-en-3β-yloxycarbonyl)butyl]imidazolium iodide | 1191385-31-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: N-methyl-N'-[4-(cholest-5-en-3β-yloxycarbonyl)butyl]imidazolium iodide
• 英文别名: CvII
• CAS: 1191385-31-5
• 化学式: C₃₆H₅₉N₂O₂*I
• 分子量: 678.781
• InChiKey: IEHMPNYDICITLF-VKRRVDNBSA-M

反应信息

• 作为产物：
  描述：

  N-(4-cholesteryloxycarbonylbutyl)imidazole 、 碘甲烷 以80%的产率得到N-methyl-N'-[4-(cholest-5-en-3β-yloxycarbonyl)butyl]imidazolium iodide
  参考文献：
  名称：

  Novel Cholesterol-Based Cationic Lipids for Gene Delivery

  摘要：

  Gene therapy based on gene delivery is a promising strategy for the treatment of human disease. Here we present data oil structure/biological activity of new biodegradable cholesterol-based cationic lipids with various heterocyclic cationic head groups and linker types. Enhanced accumulation of nucleic acids in the cells mediated by the lipids was demonstrated by fluorescent microscopy and flow cytometry. Light scattering and atomic force microscopy were used to find structure/transfection activity correlations for the lipids. We found that the ability of the lipids to stimulate intracellular accumulation of the oligodeoxyribonucleotides and plasmid DNA correlates well with their ability to form in solution lipid/NA complexes of sizes that do not exceed 100 nm. Screening of the lipids revealed the most promising transfection agents both in terms of low toxicity and efficient delivery: cholesterol-based lipids with positively charged pyridine and methyl imidazole head groups and either the ester or carbamate linker.

  DOI：

  10.1021/jm901022t