Dodecyl-[[dodecyl(dimethyl)azaniumyl]methyl]-dimethylazanium | 45304-52-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Dodecyl-[[dodecyl(dimethyl)azaniumyl]methyl]-dimethylazanium
• CAS: 45304-52-7
• 化学式: C₂₉H₆₄N₂
• 分子量: 440.841
• InChiKey: DICCXBODAZDJLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  31
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• FUNCTIONALIZED MESOPOROUS SILICA VIA AN AMINOSILANE SURFACTANT ION EXCHANGE REACTION: CONTROLLED SCAFFOLD DESIGN AND NITRIC OXIDE RELEASE
  申请人：The University of North Carolina at Chapel Hill

  公开号：EP3750624A1

  公开（公告）日：2020-12-16

  Nitric oxide-releasing mesoporous silica nanoparticles (MSNs) were prepared using an aminosilane-template surfactant ion exchange reaction. Initially, bare silica particles were synthesized under basic conditions in the presence of cetyltrimethylammonium bromide (CTAB). These particles were functionalized with nitric oxide (NO) donor precursors via the addition of aminosilane directly to the particle sol, and a commensurate ion exchange reaction between the cationic aminosilanes and CTAB. N-diazeniumdiolate NO donors were formed at the secondary amines to yield NO-releasing silica MSNs. Tuning of the ion exchange-based MSN modification approach allowed for the preparation of monodisperse particles ranging from 30 to 1100 nm. Regardless of size, the MSNs stored appreciable levels of NO (0.4-1.5 µmol/mg) with tunable NO-release durations (1-33 h) dependent on the aminosilane modification. The range of MSN sizes and NO release demonstrate the versatility of this strategy.

  利用氨基硅烷-模板表面活性剂离子交换反应制备了释放一氧化氮的介孔二氧化硅纳米粒子（MSN）。首先，在十六烷基三甲基溴化铵（CTAB）存在下，在碱性条件下合成裸二氧化硅颗粒。通过在颗粒溶胶中直接添加氨基硅烷，并在阳离子氨基硅烷和 CTAB 之间进行相应的离子交换反应，用一氧化氮（NO）供体前体对这些颗粒进行功能化。在仲胺上形成 N-二氮二酸氮氧化物供体，生成释放氮氧化物的二氧化硅 MSN。通过调整基于离子交换的 MSN 改性方法，可以制备出 30 纳米到 1100 纳米的单分散颗粒。无论大小如何，MSN 都能储存可观水平的 NO（0.4-1.5 µmol/mg），且 NO 释放持续时间（1-33 h）可调，这取决于氨基硅烷的改性。MSN 尺寸和 NO 释放的范围表明了这种策略的多功能性。