ethyl 3,4-di-O-benzoyl-2-deoxy-2-phthalimido-1-thio-6-O-trityl-β-D-glucopyranoside | 933790-88-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: ethyl 3,4-di-O-benzoyl-2-deoxy-2-phthalimido-1-thio-6-O-trityl-β-D-glucopyranoside
• CAS: 933790-88-6
• 化学式: C₄₉H₄₁NO₈S
• 分子量: 803.932
• InChiKey: SPBDWAYLQGEXJE-UMJPMJEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.59
• 重原子数：
  59.0
• 可旋转键数：
  13.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  108.44
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  ethyl 3,4-di-O-benzoyl-2-deoxy-2-phthalimido-1-thio-6-O-trityl-β-D-glucopyranoside 在 吡啶 、 甲醇 、 溶剂黄146 、 乙酰氯 作用下， 以 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 36.67h， 生成 3-(benzyloxycarbonylamino)propyl-3,4-di-O-benzoyl-2-deoxy-2-phthalimido-β-D-glucopyranoside
  参考文献：
  名称：

  [EN] METHODS FOR PROVIDING CONTINUOUS THERAPY AGAINST PNAG COMPRISING MICROBES
  [FR] PROCÉDÉS POUR FOURNIR UNE THÉRAPIE CONTINUE CONTRE DES MICROBES CONTENANT PNAG

  摘要：

  披露了包含寡糖β-(1→6)-葡萄糖胺基团的抗微生物疫苗。

  公开号：

  WO2021102320A1
• 作为产物：
  描述：

  乙基3,4,6-三-O-乙酰基-2-脱氧-2-邻苯二甲酰亚胺基-1-硫代-β-D-吡喃葡萄糖苷 在 吡啶 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 9.83h， 生成 ethyl 3,4-di-O-benzoyl-2-deoxy-2-phthalimido-1-thio-6-O-trityl-β-D-glucopyranoside
  参考文献：
  名称：

  Methods for inhibiting biofilm formation

  摘要：

  本文披露了一种用于抑制易于形成生物膜的方法和配件套件，适用于处于发展生物膜风险中的受试者体内。这些方法包括在生物膜中抑制生物膜形成，其中生物膜的细胞外基质包括聚β-(1→6)葡聚糖结构。

  公开号：

  US10828360B1

文献信息

• [EN] LOW CONTAMINANT ANTIMICROBIAL VACCINES<br/>[FR] VACCINS ANTIMICROBIENS À FAIBLE TENEUR EN CONTAMINANTS
  申请人：ONEBIOPHARMA INC

  公开号：WO2021096921A1

  公开（公告）日：2021-05-20

  Disclosed are antimicrobial vaccines comprising oligosaccharide β-(1→6)-glucosamine groups.

  披露了包含寡糖β-(1→6)-葡萄糖胺基团的抗微生物疫苗。
• [EN] ANTIMICROBIAL VACCINE COMPOSITIONS<br/>[FR] COMPOSITIONS DE VACCINS ANTIMICROBIENS
  申请人：ONEBIOPHARMA INC

  公开号：WO2021041721A8

  公开（公告）日：2021-05-14
• The study of the reaction of terminated oligomerization in the synthesis of oligo-(β1-6)-glucosamines
  作者：M. L. Gening、Yu. E. Tsvetkov、G. B. Pier、N. E. Nifantiev

  DOI：10.1134/s1068162006040108

  日期：2006.7

  The applicability of terminated oligomerization to the synthesis of oligo-(beta 1-6)-glucosamines, fragments of the intercellular polysaccharide adhesin of staphylococci, was studied. The reactions of terminated oligomerization were carried out with mono-, di-, and trisaccharide monomers and N-protected aminopropanol; and spacered mono- and disaccharides as terminating molecules were also attempted. The primary formation of cyclic products of monomer intramolecular glycosylation was observed in almost all the reactions. Only the experiments with the monomer based on the disaccharide bromide under the conditions of the Helferich reaction led to reduced yields (30%) of the cyclic products. However, even in this case, the desired terminated oligosaccharides were generated in approximately 10% yield and mainly were the products of single glycosylation of the terminator by the monomer. These experiments allow the conclusion that, under the examined conditions, the reaction of terminated oligomerization could not result in the synthesis of oligoglucosamines with a high molecular mass.
• Comparison of the Armed/Disarmed Building Blocks of the <scp>d</scp>-Gluco and <scp>d</scp>-Glucosamino Series in the Context of Chemoselective Oligosaccharide Synthesis
  作者：Teerada Kamkhachorn、Archana R. Parameswar、Alexei V. Demchenko

  DOI：10.1021/ol101089u

  日期：2010.7.2

  A very elegant Fraser-Reid armed-disarmed approach recently expanded to the building blocks of the superarmed and superdisarmed series shows very high utility in chemoselective oligosaccharide synthesis. Although a number of studies dedicated to the chemoselective activation of 2-amino-2-deoxysugars have emerged, little remains known about how the reactivity of the armed/disarmed building blocks of the neutral sugars directly compares to that of their 2-aminosugar counterparts. A preliminary study of this comparative reactivity is presented.