5,6,7,8-Tetrahydro-9-mercapto-2-methyl-s-triazolo[5,1-b]quinazoline | 1211488-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5,6,7,8-Tetrahydro-9-mercapto-2-methyl-s-triazolo[5,1-b]quinazoline
• CAS: 1211488-00-4
• 化学式: C₁₀H₁₂N₄S
• 分子量: 220.298
• InChiKey: DWGIAKDWWFNVSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.08
• 氢给体数：
  1.0
• 氢受体数：
  5.0

文献信息

• Beta-Lactam compound, method for preparing the same, medicinal composition for bacterially infectious disease therapy containing the same and intermediates for synthesis of the same
  申请人：SANKEI PHARMACEUTICAL COMPANY LIMITED

  公开号：EP0254495A2

  公开（公告）日：1988-01-27

  There are disclosed a β-lactam compound represented by the formula (I): wherein R₁ and R₂ are independently a hydrogen atom or a lower alkyl group; M is a hydrogen atom, a protective group or an eliminatable group which is easily hydrolyzable in a human body; Rʹ and Rʺ are independently a hydrogen atom or a protective group; A is a mercapto group substituted by a sub­stituted or unsubstituted polycyclic nitrogen-con­taining heterocyclic ring or a group represented by the following formula (a):     -OOCNR₃R₄      (a) where R₃ and R₄ are independently a hydrogen atom or a lower alkyl group, provided that R₁ and R₂ are both hydrogen atoms, both R₃ and R₄ being hydrogen atoms are excluded, or its pharmaceutically acceptable salt, and a method for preparing the same, medicinal composition for microbism therapy containing the same and intermediates for synthesis of the same.

  本发明公开了一种β-内酰胺化合物，由式(I)表示： 其中 R₁ 和 R₂ 独立地为氢原子或低级烷基；M 为氢原子、保护基团或在人体内易水解的可消除基团；Rʹ 和 Rʺ 独立地为氢原子或保护基团；A 为被取代或未取代的多环含氮杂环取代的巯基或下式(a)所代表的基团： -OOCNR₃R₄ (a) 其中 R₃ 和 R₄ 独立地为氢原子或低级烷基、 但 R₁ 和 R₂ 均为氢原子，R₃ 和 R₄ 均为氢原子者除外、 或其药学上可接受的盐，以及制备上述物质的方法、含有上述物质的微生物治疗药物组合物和合成上述物质的中间体。
• US4966900A
  申请人：——

  公开号：US4966900A

  公开（公告）日：1990-10-30