3-acetoxy-5-(2-dimethylamino-ethyl)-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one | 124808-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 3-acetoxy-5-(2-dimethylamino-ethyl)-2-p-tolyl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one
• 英文别名: [5-[2-(Dimethylamino)ethyl]-2-(4-methylphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
• CAS: 124808-38-4
• 化学式: C₂₂H₂₆N₂O₃S
• 分子量: 398.526
• InChiKey: IRSZGKNBNQQXKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  75.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• sGC Stimulators
  申请人：Kim Charles

  公开号：US20120184516A1

  公开（公告）日：2012-07-19

  Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

  描述了化学式I的化合物。它们可用作sGC的刺激剂，特别是NO独立的、血红素依赖性的刺激剂。这些化合物可能有助于治疗、预防或管理本文中披露的各种疾病。
• sGC STIMULATORS
  申请人：IRONWOOD PHARMACEUTICALS, INC.

  公开号：US20160031903A1

  公开（公告）日：2016-02-04

  Compounds of Formulae I′ and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

  本文描述了化学式I'和I的化合物，它们可用作sGC的刺激剂，特别是NO独立，血红素依赖性的刺激剂。这些化合物还可用于治疗、预防或管理本文中披露的各种疾病。
• PYRAZOLE DERIVATIVES AS SGC STIMULATORS
  申请人：IRONWOOD PHARMACEUTICALS, INC.

  公开号：US20170291889A1

  公开（公告）日：2017-10-12

  Compounds are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.
• US8748442B2
  申请人：——

  公开号：US8748442B2

  公开（公告）日：2014-06-10
• US9139564B2
  申请人：——

  公开号：US9139564B2

  公开（公告）日：2015-09-22