钠氰胺 | 19981-17-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 钠氰胺
• 英文名称: Sodium hydrogen cyanamide
• CAS: 19981-17-0
• 化学式: CH2N2Na
• 分子量: 65.03
• InChiKey: JWEKFMCYIRVOQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.95
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  钠氰胺 、 4-氯异硫氰酸苯酯 在 乙醇 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以to give the title A compound (5.4 g), m.p. >250° C.的产率得到N-(4-chlorophenyl)-N'-cyanothiourea
  参考文献：
  名称：

  Pyranyl cyanoguanidine derivatives

  摘要：

  公开了具有以下式子的新化合物：##STR1## 其中 ##STR2## 这些化合物具有钾通道激活活性，并且可以用作心血管药物，特别是抗缺血剂。

  公开号：

  US05140031A1

文献信息

• Sweetening agents
  申请人：Universite Claude Bernard -Lyon 1

  公开号：US04921939A1

  公开（公告）日：1990-05-01

  Substituted guanidines and ethanamidines are provided as high potency sweetening agents.

  提供了替代胍和乙酰胍作为高效的甜味剂。
• Acylated cyanamide compounds
  申请人：Regents of the University of Minnesota

  公开号：US04940816A1

  公开（公告）日：1990-07-10

  Acylated cyanamide compounds useful for ethanol deterrence of the formula RCONHCN, wherein R is a lipophilic acyl group or is derived from an (N-substituted)-alpha-aminoacyl group.

  以下是翻译结果： 酰化氰胺化合物对乙醇具有阻止作用，其化学式为RCONHCN，其中R为亲脂性酰基或由（N-取代）-α-氨基酰基基团衍生。
• Novel sweetening agents, process for sweetening various products and
  申请人：Universite Claude Bernard/Lyon 1

  公开号：US04673582A1

  公开（公告）日：1987-06-16

  Sweetening agents of general formula: ##STR1## wherein: X is a CN, COOC.sub.1 -C.sub.3 alkyl, COC.sub.1 -C.sub.3 alkyl, CONHC.sub.1 -C.sub.3 alkyl, SO.sub.2 C.sub.1 -C.sub.3 alkyl, SOC.sub.1 -C.sub.3 alkyl, SO.sub.2 NHC.sub.1 -C.sub.3 alkyl, NO.sub.2, F, Cl substituent; n is a number equal to 0 or 1; M is a hydrogen atom, or an organic or inorganic physiologically acceptable cation; Y is a COOC.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkyl, CH.sub.2 OH, CHOHCH.sub.3, CF.sub.3 substituent; Z is a C.sub.1 -C.sub.5 n-alkyl, isobutyl, isopentyl, phenyl, cyclohexyl, benzyl, cyclohexylmethyl, CH.sub.2 C.sub.6 H.sub.4 OH(p), CH.sub.2 OC.sub.1 -C.sub.4 alkyl, CH.sub.2 COOC.sub.1 -C.sub.4 alkyl, CH.sub.2 SC.sub.1 -C.sub.4 alkyl, CH.sub.2 CH.sub.2 SCH.sub.3, CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3, COOC.sub.1 -C.sub.4 alkyl, COOC.sub.3 -C.sub.7 cycloalkyl, CONHC.sub.2 -C.sub.4 alkyl, CONHC.sub.3 -C.sub.7 cycloalkyl, CONHC.sub.3 -C.sub.7 thiacycloalkyl, or CONHCH.sub.2 COOCH.sub.3 group; characterized in that A is an N--CN group.

  一般式为：##STR1## 其中：X为CN，COOC.sub.1 -C.sub.3烷基，COC.sub.1 -C.sub.3烷基，CONHC.sub.1 -C.sub.3烷基，SO.sub.2 C.sub.1 -C.sub.3烷基，SOC.sub.1 -C.sub.3烷基，SO.sub.2 NHC.sub.1 -C.sub.3烷基，NO.sub.2，F，Cl取代基；n为0或1；M为氢原子或有机或无机生理上可接受的阳离子；Y为COOC.sub.1 -C.sub.3烷基，C.sub.1 -C.sub.3烷基，CHOHCH.sub.3，CF.sub.3取代基；Z为C.sub.1 -C.sub.5正烷基，异丁基，异戊基，苯基，环己基，苄基，环己基甲基，CH.sub.2 C.sub.6 H.sub.4 OH(p)，CH.sub.2 OC.sub.1 -C.sub.4烷基，CH.sub.2 COOC.sub.1 -C.sub.4烷基，CH.sub.2 SC.sub.1 -C.sub.4烷基，CH.sub.2 CH.sub.2 SCH.sub.3，CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.3，COOC.sub.1 -C.sub.4烷基，COOC.sub.3 -C.sub.7环烷基，CONHC.sub.2 -C.sub.4烷基，CONHC.sub.3 -C.sub.7环烷基，CONHC.sub.3 -C.sub.7硫代环烷基，或CONHCH.sub.2 COOCH.sub.3基团；其特征在于A为N--CN基团。
• Phosphinic ester substituted benzopyran derivatives
  申请人：Bristol-Myers Squibb Company

  公开号：US05612323A1

  公开（公告）日：1997-03-18

  ##STR1## and pharmaceutically acceptable salts thereof wherein Y is a single bond, --CH.sub.2 --, --C(O)--, --S-- or --N(R.sup.11)--; and R.sup.1 to R.sup.6 are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.

  本发明涉及一种化合物，其通式为##STR1##及其药学上可接受的盐，其中Y是单键，-CH.sub.2-，-C（O）-，-S-或-N（R.sup.11）-; R.sup.1至R.sup.6如本文所定义。这些化合物具有钾通道激活活性，因此例如可用作心血管药物。
• 6-aryl-3-cyanaminopyridazines, their preparation and use and medicaments
  申请人：BYK Gulden Lomberg Chemische Fabrik GmbH

  公开号：US05236918A1

  公开（公告）日：1993-08-17

  6-Aryl-3-cyanaminopyridazines and their salts with bases, as well as pharmaceutical compositions containing them, have anti-inflammatory and broncholytic activity, low toxicity and the absence of substantial side effects.

  6-Aryl-3-cyanaminopyridazines及其与碱盐的药物组合物具有抗炎和支气管扩张作用，毒性低且不存在重大副作用。