| 1176281-04-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• CAS: 1176281-04-1
• 化学式: C₇₀H₉₉NO₈
• 分子量: 1082.56
• InChiKey: VDNXMZHJHCTQFP-KAWOHUCSSA-N

反应信息

• 作为反应物：
  描述：

  在 氢气 、 palladium(II) hydroxide 作用下， 以 乙醇 为溶剂， 以89%的产率得到N-[(2S,3R)-3-hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonan-2-yl]icosanamide
  参考文献：
  名称：

  Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH

  摘要：

  An alpha-galactosyl ceramide (alpha-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKTcell proliferation and elicit T-helper cytokines, IL-4 and IFN gamma. Compound 2 combines the acyl chain of the potent, Th2 biasing alpha-GalCer 1 with a sphingoid base of the same length as that found in OCH, which also exhibits Th2 skewing, Such complementation may enhance cytokine bias, which is thought to be important for therapeutic applications of iNKT cell stimulation. Two related alpha-GalCers, 3 and 4, with saturated acyl chains were prepared for comparison. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.042
• 作为产物：
  描述：

  、 2,3,4,6-tetrakis-O-(phenylmethyl)-β-D-galactopyranosyl fluoride 在 silver perchlorate 、 tin(ll) chloride 作用下， 以 四氢呋喃 为溶剂， 以45%的产率得到
  参考文献：
  名称：

  Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH

  摘要：

  An alpha-galactosyl ceramide (alpha-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKTcell proliferation and elicit T-helper cytokines, IL-4 and IFN gamma. Compound 2 combines the acyl chain of the potent, Th2 biasing alpha-GalCer 1 with a sphingoid base of the same length as that found in OCH, which also exhibits Th2 skewing, Such complementation may enhance cytokine bias, which is thought to be important for therapeutic applications of iNKT cell stimulation. Two related alpha-GalCers, 3 and 4, with saturated acyl chains were prepared for comparison. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.042