N,N,2-trimethylpropanimidamide | 321881-25-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N,2-trimethylpropanimidamide
• CAS: 321881-25-8
• 化学式: C₆H₁₄N₂
• 分子量: 114.19
• InChiKey: MNSQSJWQUTWSOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  27.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] PANTETHENOYLCYSTEINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PANTÉTHÉNOYLCYSTÉINE ET LEURS UTILISATIONS
  申请人：COMET THERAPEUTICS INC

  公开号：WO2020198573A1

  公开（公告）日：2020-10-01

  The present disclosure relates to compounds of Formula (I) or (II): (Formulae (I), (II)), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

  本公开涉及式(I)或(II)的化合物：(式(I)，(II))，以及其药用可接受的盐或溶剂化合物。本公开还涉及包含这些化合物的药物组合物，以及这些化合物和药物组合物的治疗和诊断用途。
• FACTOR Xa INHIBITORS
  申请人：Zhu Bing-Yan

  公开号：US20070185092A1

  公开（公告）日：2007-08-09

  The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

  本发明涉及由式（I）表示的化合物，或其药学上可接受的盐、酯或前药，其是因子Xa的抑制剂。本发明还涉及用于制备这种化合物的中间体，含有这种化合物的制药组合物，用于预防或治疗由不良血栓形成所表征的多种疾病的方法，以及抑制血液样品凝血的方法。
• FACTOR XA INHIBITORS
  申请人：Zhu Bing-Yan

  公开号：US20090298806A1

  公开（公告）日：2009-12-03

  The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

  本发明涉及由公式I表示的化合物及其药学上可接受的盐、溶剂化合物、水合物和前药，这些化合物是凝血因子Xa的抑制剂。本发明还涉及制备这些化合物所使用的中间体，含有这些化合物的药物组合物，预防或治疗一系列由不良血栓形成表征的疾病的方法，以及抑制血样的凝血的方法。
• Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them
  申请人：The Boots Company PLC

  公开号：EP0385038A1

  公开（公告）日：1990-09-05

  Compounds of formula I and their salts in which n = 0 or 1, R1 and R2 are each aliphatic or cycloalkyl or NR1 R2 is an optionally substituted heterocyclic ring, R3 is alkyl, cycloalkyl or optionally substituted amino, R5 is an aliphatic group, R6 is H, an optionally substituted aliphatic group or a cycloalkyl group, or R3 and R5 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R5 and R6 together with the nitrogen to which they are attached form a heterocyclic ring optionally substituted by alkyl and R7 is optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, trifluoromethyl or cyano have utility as hypoglycaemic agents.

  式 I 的化合物及其盐类 及其盐类，其中 n = 0 或 1，R1 和 R2 各为脂肪族或环烷基或 NR1 R2 为任选取代的杂环，R3 为烷基、环烷基或任选取代的氨基，R5 为脂肪族基团，R6 为 H、任选取代的脂肪族基团或环烷基基团、或 R3 和 R5 与它们所连接的氮原子和碳原子一起形成一个任选取代的杂环，或 R5 和 R6 与它们所连接的氮原子一起形成一个任选被烷基取代的杂环，R7 是任选取代的烷基、烷氧基、烷硫基、烷基亚砜基、烷基磺酰基、烷氧基羰基、三氟甲基或氰基。
• METALL COMPLEX COMPRISING AMIDINE AND SUBSTITUTED CYCLOPENTADIENYL LIGANDS
  申请人：Arlanxeo Netherlands B.V.

  公开号：EP3272761A1

  公开（公告）日：2018-01-24

  The present invention relates to a metal complexes of formula (1), which is:          CyLMZ p      (1), comprising a substituted cyclopentadienyl ligand (Cy) and an amidinate ligand (L), Cy is a substituted cyclopentadienyl ligand that contains the substituents R1, R2 and 3 additional methyl groups, whereof two of the methyl groups, provided they are vicinal may optionally be exchanged by an anellated C6-C10 aromatic ring, wherein R1 means H, halogen or a C3-C20 substituent R2 means a C1-C20 substituent L is represented by either formula (2) or (2b). Further claims relate to a catalyst system containing said metal complex and a process for manufacturing polymers wherein said metal complex or catalyst system is used.

  本发明涉及式（1）的金属络合物，即 CyLMZ p (1)、 Cy 是取代的环戊二烯基配体，含有取代基 R1、R2 和 3 个额外的甲基，其中 2 个甲基（如果是沧侧甲基）可以选择性地与一个酰胺化的 C6-C10 芳环交换，其中 R1 指 H、卤素或 C3-C20 取代基 R2 指 C1-C20 取代基 L 由式 (2) 或 (2b) 表示。 进一步的权利要求涉及含有所述金属络合物的催化剂体系，以及使用所述金属络合物或催化剂体系的聚合物生产工艺。