17α-Hydroxymethyl-androst-5-en-3β,17β-diol | 901-51-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17α-Hydroxymethyl-androst-5-en-3β,17β-diol
• 英文别名: (3S,8R,9S,10R,13S,14S,17S)-17-(hydroxymethyl)-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-diol
• CAS: 901-51-9
• 化学式: C₂₀H₃₂O₃
• 分子量: 320.472
• InChiKey: SHSSCYPJISZJMP-IJMQKCTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  17α-Hydroxymethyl-androst-5-en-3β,17β-diol 在 盐酸 、 高氯酸 作用下， 以 吡啶 、 乙醇 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Szilagyi; Solyom; Toldy, Acta Chimica Hungarica, 1984, vol. 116, # 2, p. 111 - 123

  摘要：

  DOI：
• 作为产物：
  描述：

  3β-hydroxyspiro 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 17α-Hydroxymethyl-androst-5-en-3β,17β-diol
  参考文献：
  名称：

  Bertin,D.; Nedelec,L., Bulletin de la Societe Chimique de France, 1964, p. 2140 - 2144

  摘要：

  DOI：

文献信息

• Drug product and process for making
  申请人：Frincke M. James

  公开号：US20070053832A1

  公开（公告）日：2007-03-08

  The invention provides a drug product for treating radiation exposure comprising, a drug in a dosage form; and packaging for the drug together with a package insert or label that includes information about the drug's efficacy, where the information about the drug's efficacy is obtained at least in part from methods described in the disclosure.
• Surrogate markers
  申请人：Garsd Armando

  公开号：US20070077203A1

  公开（公告）日：2007-04-05

  The invention provides a method to analyze an effect of a biological insult such as exposure to ionizing radiation comprising (a) exposing one or more groups of subjects to a biological insult of at least about an LD 10 to obtain one or more groups of exposed subjects; and (b) measuring one, two, three or more surrogate markers in one or more of the groups of exposed subjects, wherein one, two, three or more of the surrogate markers correlate with death at a P≦0.1.
• Drug Product and Process for Making
  申请人：Frincke James M.

  公开号：US20110085984A1

  公开（公告）日：2011-04-14

  The invention provides a drug product for treating radiation exposure comprising, a drug in a dosage form; and packaging for the drug together with a package insert or label that includes information about the drug's efficacy, where the information about the drug's efficacy is obtained at least in part from methods described in the disclosure.
• Screening and Treatment Method
  申请人：Garsd Armando

  公开号：US20120029260A1

  公开（公告）日：2012-02-02

  The invention provides a method to analyze an effect of a biological insult such as exposure to ionizing radiation comprising (a) exposing one or more groups of subjects to a biological insult of at least about an LD 10 to obtain one or more groups of exposed subjects; and (b) measuring one, two, three or more surrogate markers in one or more of the groups of exposed subjects, wherein one, two, three or more of the surrogate markers correlate with death at a P≦0.1.