Quarfloxin, (S)- | 783364-52-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: Quarfloxin, (S)-
• 英文别名: 15-fluoro-N-[2-[(2S)-1-methylpyrrolidin-2-yl]ethyl]-18-oxo-14-[(3S)-3-pyrazin-2-ylpyrrolidin-1-yl]-12-oxa-1-azapentacyclo[11.7.1.02,11.04,9.017,21]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxamide
• CAS: 783364-52-3
• 化学式: C₃₅H₃₃FN₆O₃
• 分子量: 604.7
• InChiKey: WOQIDNWTQOYDLF-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  45
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  90.9
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• COMBINATION CANCER CHEMOTHERAPY
  申请人：Hurley Laurence H.

  公开号：US20090270377A1

  公开（公告）日：2009-10-29

  Provided is a method for improving treatment of a neoplastic condition by combining a therapeutically effective amount of a polyADP-ribose polymerase inhibitor with a therapeutically effective amount of a compound which triggers the release of nucleolin from the G-quadruplexes in rDNA. As specifically exemplified, the compound which increases nucleolin binding is a substituted quinobenzoxazine analog, for example CX-3543.