4,4-dimethyl-5α-cholesta-8,14-dien-3β-ol | 20938-51-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4,4-dimethyl-5α-cholesta-8,14-dien-3β-ol
• 英文别名: 4,4-Dimethylcholesta-8,14-diene-3β-ol；(3S,10S,13R,17R)-4,4,10,13-tetramethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol
• CAS: 20938-51-6
• 化学式: C₂₉H₄₈O
• 分子量: 412.7
• InChiKey: OGQJUYXFIOFTMA-ZKRAVAGISA-N

物化性质

• 沸点：
  510.1±49.0 °C(Predicted)
• 密度：
  0.99±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Meiosis regulating compounds
  申请人：——

  公开号：US20020013302A1

  公开（公告）日：2002-01-31

  Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.

  甾醇衍生物化合物，结构上与可以从公牛睾丸和人类卵泡液中提取的天然化合物相关，对调节卵母细胞和男性生殖细胞中的减数分裂有用。其中一些化合物对治疗不孕症有用，而其他化合物则可用作避孕药。
• Regulation of meiosis
  申请人：——

  公开号：US20030004148A1

  公开（公告）日：2003-01-02

  Compounds of Formula I and methods of regulating the meiosis in a mammalian germ cell which method comprises administering an effective amount of the compound of Formula I to a germ cell in need of such a treatment.

  公式I的化合物和调控哺乳动物生殖细胞减数分裂的方法，所述方法包括向需要此类治疗的生殖细胞中施用公式I的化合物的有效量。
• Compositions for the treatment of cataracts
  申请人：Catacore, Inc.

  公开号：US10398709B2

  公开（公告）日：2019-09-03

  In one embodiment, the present application discloses an aqueous ophthalmic composition for the treatment of eye diseases, lesions and injuries, comprising: a) one steroid, or a combination of at least two steroids selected from the group consisting of lanosterol, dihydrolanosterol, 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol, 4,4-dimethylcholesta-8,24-dien-3β-ol, 4,4-dimethylcholesta-8-en-3β-ol, 4,4-dimethylcholesta-8(9),14-dien-3β-ol, 14-desmethyl lanosterol, lathosterol, Δ7,24-cholestadienol, cholesterol, cholesta-7-enol, cholesteryl ester, 7-dehydrocholesterol, desmosterol, 7-dehydrodesmosterol, zymosterol, 27-hydroxycholesterol, cholesta-7,24-dien-3-β-ol, cholesta-8(9)-en-3-β-ol, 5α-cholestan-3β-ol-6-one, 5-cholesten-3β,25-diol, 5-cholesten-3β,25-OSO3H (5-cholesten-3β,25-sulfate), 5-cholesten-3β-OSO3H,25-ol (5-cholesten-3β-sulfate,25-ol), 5-cholesten-3β,25-diol, disulfate, and their esters thereof, or a pharmaceutically acceptable salt thereof, in a concentration effective for the treatment and/or prophylaxis of the eye diseases, lesions and injuries; and b) a pharmaceutical excipient; and methods of treatment using such compositions.

  在一个实施方案中，本申请公开了一种用于治疗眼部疾病、病变和损伤的水性眼科组合物，该组合物包括a) 一种类固醇，或至少两种类固醇的组合，选自由羊毛甾醇、二氢羊毛甾醇、4,4-二甲基胆甾-8(9),14,24-三烯-3β-醇、4,4-二甲基胆甾-8,24-二烯-3β-醇、4,4-二甲基胆甾-8-烯-3β-醇组成的组、4,4-二甲基胆甾烯-8(9),14-二烯-3β-醇、14-去甲基羊毛甾醇、羊毛甾醇、Δ7,24-胆甾烯醇、胆固醇、胆甾-7-烯醇、胆固醇酯、7-脱氢胆固醇、去甾醇、7-脱氢去甾醇、去甾醇、27-hydroxycholesterol, cholesta-7,24-dien-3-β-ol, cholesta-8(9)-en-3-β-ol, 5α-cholestan-3β-ol-6-one, 5-cholesten-3β,25-diol, 5-cholesten-3β,25-OSO3H (5-cholesten-3β,25-sulfate), 5-cholesten-3β-OSO3H,25-ol (5-cholesten-3β-sulfate. 25-ol), 5-cholesten-3β-Sulfate、25-醇）、5-胆甾烯-3β,25-二醇、二硫酸盐和它们的酯，或它们的药学上可接受的盐，其浓度对治疗和/或预防眼病、病变和损伤有效；b) 药用辅料；以及使用此类组合物的治疗方法。
• STEROL DERIVATIVES USED FOR REGULATION OF MEIOSIS
  申请人：NOVO NORDISK A/S

  公开号：EP0767798B1

  公开（公告）日：2003-09-03
• MEIOSIS REGULATING COMPOUNDS
  申请人：NOVO NORDISK A/S

  公开号：EP0857173A1

  公开（公告）日：1998-08-12