N1-Pr-N2-CN-N3-Me guanidine | 120399-48-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N1-Pr-N2-CN-N3-Me guanidine
• 英文别名: 1-cyano-2-methyl-3-propylguanidine
• CAS: 120399-48-6
• 化学式: C₆H₁₂N₄
• 分子量: 140.188
• InChiKey: CYFPVACSJLXVCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] DIFFERENTIALLY EXPRESSED IMMUNE CELL MICRORNAS FOR REGULATION OF PROTEIN EXPRESSION<br/>[FR] MICROARN DE CELLULES IMMUNITAIRES EXPRIMÉS DE MANIÈRE DIFFÉRENTIELLE POUR LA RÉGULATION DE L'EXPRESSION DE PROTÉINES
  申请人：MODERNATX INC

  公开号：WO2020227537A1

  公开（公告）日：2020-11-12

  The disclosure features mRNAs engineered with one or more microRNA binding sites targeted by a microRNA(s) that are differentially expressed in a target immune cell relative to a plurality of non-target immune cells. The disclosure also features methods of using the same, for example, for selectively degrading the mRNA in the target immune cell relative to the plurality of non-target immune cells.
• [EN] MRNAS ENCODING METABOLIC REPROGRAMMING POLYPEPTIDES AND USES THEREOF<br/>[FR] ARNM CODANT DES POLYPEPTIDES DE REPROGRAMMATION MÉTABOLIQUE ET LEURS UTILISATIONS
  申请人：MODERNATX INC

  公开号：WO2021155267A2

  公开（公告）日：2021-08-05

  The disclosure features lipid nanoparticle (LNP) compositions comprising metabolic reprogramming molecules and uses thereof. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding metabolic reprogramming polypeptides, e.g., IDO, TDO, AMPK, AhR, ALDH1A2, HMOX1, CD73 or CD39. The LNP compositions of the present disclosure can reprogram myeloid and/or dendritic cells, suppress T cells and/or induce immune tolerance in vivo.