4'-(苄氧基)-alpha,beta-二乙基-4-二苯乙烯醇 | 6202-26-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 4'-(苄氧基)-alpha,beta-二乙基-4-二苯乙烯醇
• 英文名称: 4-[1-ethyl-2-(4-benzyloxy-phenyl)-but-1-en-c-yl]-phenol
• 英文别名: 4-[1-Aethyl-2-(4-benzyloxy-phenyl)-but-1-en-c-yl]-phenol；trans-4-(1-Ethyl-2-(4-(phenylmethoxy)phenyl)-1-butenyl)phenol；4-[(E)-4-(4-phenylmethoxyphenyl)hex-3-en-3-yl]phenol
• CAS: 6202-26-2
• 化学式: C₂₅H₂₆O₂
• 分子量: 358.48
• InChiKey: FVLDPSZNPFWQQP-OCOZRVBESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氯化苄 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 4'-(苄氧基)-alpha,beta-二乙基-4-二苯乙烯醇
  参考文献：
  名称：

  US2658080

  摘要：

  公开号：

文献信息

• EP1617859A1
  申请人：——

  公开号：EP1617859A1

  公开（公告）日：2006-01-25
• Methods and compositions using gonadotropin hormone releasing hormone
  申请人：Porchet Herve

  公开号：US20070042040A1

  公开（公告）日：2007-02-22

  The present invention relates to compositions comprising two sustained release formulations, the first being capable of releasing a gonadotropin releasing hormone composition and the second an estrogenic composition. The compositions of the invention can be employed for an improved androgen deprivation therapy of prostate cancer, in which therapy loss of bone mineral density and the occurrence and severity of hot flashes are minimized through the maintenance of a minimally adequate estrogen level.
• [EN] METHODS AND COMPOSITIONS USING GONADOTROPIN HORMONE RELEASING HORMONE<br/>[FR] METHODES ET COMPOSITIONS METTANT EN OEUVRE LA GONADOLIBERINE
  申请人：DEBIOPHARM SA

  公开号：WO2004096259A1

  公开（公告）日：2004-11-11

  The present invention relates to compositions comprising two sustained release formulations, the first being capable of releasing a gonadotropin releasing hormone composition and the second an estrogenic composition. The compositions of the invention can be employed for an improved androgen deprivation therapy of prostate cancer, in which therapy loss of bone mineral density and the occurrence and severity of hot flashes are minimized through the maintenance of a minimally adequate estrogen level.
• [EN] COMPOSITIONS AND METHODS RELATED TO DISSOLVED OXIDES<br/>[FR] COMPOSITIONS ET PROCÉDÉS ASSOCIÉS À DES OXYDES DISSOUS
  申请人：NATURAL EXTRACTION SYS LLC

  公开号：WO2021042001A1

  公开（公告）日：2021-03-04

  Various aspects of this patent document relate to compositions that comprise an anion that is the conjugate base of a hydrophobic molecule that has a pKa, for example, of at least 7 and no greater than 12. These compositions display improved properties when formulated to interact with an organism because the anions carry negative charges that allows them to both dissolve in water-miscible liquids and maximize their surface area. Interaction with an organism results in at least partial conversion of the anion into the hydrophobic molecule after which the hydrophobic molecule partitions out of a water-miscible liquid and into the organism.
• [EN] METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES<br/>[FR] PROCÉDÉS LIÉS À DES AGENTS BIOACTIFS QUI CONVERTISSENT DES ANIONS EN MOLÉCULES
  申请人：NATURAL EXTRACTION SYS LLC

  公开号：WO2021158573A1

  公开（公告）日：2021-08-12

  Various aspects of this patent document relate to bioactive compositions comprising anions that are converted into hydrophobic bioactive molecules either ex vivo prior to administration to a subject or in situ subsequent to administration to a subject. Such compositions display improved bioavailability and pharmacokinetics relative to compositions that comprise the hydrophobic bioactive molecules instead of the anions.